Informations générales (source: ClinicalTrials.gov)
COrtical Superficial Siderosis and REcurrent Lobar Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. (CORELIA)
Interventional
N/A
University Hospital, Toulouse (Voir sur ClinicalTrials)
octobre 2018
février 2025
28 août 2024
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage
(ICH) in the elderly with high risk of recurrence.
The investigators aim to determine the relationship between cortical superficial
siderosis (cSS), a MRI hemorrhagic marker of CAA and the risk of symptomatic ICH
recurrence in a multicentric prospective cohort of patients with acute lobar ICH related
to CAA. The investigators hypothesize that patients with cSS have an increased risk of
recurrent symptomatic ICH relative to those without cSS.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Purpan. Hôpital Pierre-Paul Riquet - 31059 - Toulouse cedex 9 - France | Nicolas RAPOSO, MD | Contact (sur clinicalTrials) | |||
| Gui de Chauliac Hospital - Montpellier - France | Caroline ARQUIZAN | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Lariboisière Hospital - Paris - France | Eric JOUVENT | Contact (sur clinicalTrials) | |||
| Pellegrin Hospital - Bordeaux - France | Igor SIBON | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Lobar ICH within 30 days after onset
- Available brain MRI sequences of adequate quality including fluid-attenuated
inversion recovery (FLAIR) and T2*-weighted gradient-recalled echo (T2*-GRE)
sequences.
- Modified Boston criteria for probable or possible CAA
- Age ≥ 55 years
- Written consent
- Lobar ICH within 30 days after onset
- Available brain MRI sequences of adequate quality including fluid-attenuated
inversion recovery (FLAIR) and T2*-weighted gradient-recalled echo (T2*-GRE)
sequences.
- Modified Boston criteria for probable or possible CAA
- Age ≥ 55 years
- Written consent
- Secondary brain hemorrhage : vascular malformation (arteriovenous malformation,
aneurysm, cavernous); cerebral veinous thrombosis; brain tumor; coagulopathy;
vasculitis; hemorrhagic infarction,
- Infratentorial siderosis
- Contraindications to MRI
- Neurosurgical intervention before inclusion,
- Progressive neoplasm
- Patient without affiliation to the french social security
- Patient under guardianship