Informations générales (source: ClinicalTrials.gov)

NCT03548428 En recrutement IDF
Randomized Phase II, 2-arm Study of Immunomodulation with Atezolizumab Concomitant with High Dose Radiation (SBRT) Versus SBRT Alone in Patients with Oligometastatic Sarcomas
Interventional
  • Sarcomes
Phase 2
Centre Antoine Lacassagne (Voir sur ClinicalTrials)
juin 2020
février 2031
04 septembre 2025
Up to 50% of soft tissue sarcoma (STS) patients will develop metastases in the course of their disease. Cytotoxic therapy is a standard treatment in this setting but yields average tumor response rates of 25% at first line and ≤10% at later lines. It is also limited in the number of lines and courses by tolerance issues. Trials include poly/oligometastases indistinctively and suggest that consolidation ablation is used in ~20% of patients with residual oligometastases refractory to chemotherapy. Oligometastases represent a stage of disease between completely absent and widely metastatic, and which might be cured if the limited numbers of metastatic sites are eradicated. Ablative strategies to treat patients with oligometastases from sarcomas yield prolonged survival times and stereotactic body radiation therapy (SBRT) is associated with excellent tolerance. Surgery may be offered in selected metastatic cases. Alternatively and increasingly, SBRT yields high control rates at treated sites (≥ 80%). The so-called radioresistance of sarcomas is overcome by the high doses per fraction made possible owing to the high precision achieved with SBRT. SBRT is an accepted treatment strategy provided that tumor burden remains limited in the number and size of metastases. Systemic treatment can be combined with SBRT. SBRT may produce abscopal effects where tumors outside the irradiation area also demonstrate tumor shrinkage in some occurrences. SBRT produces systemic antitumoral immune response in certain conditions and enhances radiation-induced tumor cell death compared to conventional lower dose irradiation. Abscopal effects have been potentialized with SBRT/immunotherapy in several tumor models. Sarcomas are a privileged target tumor given their high metastatic propensity. Several potent immunomodulators that skew the tumor immune microenvironment toward a proimmunity context are being investigated in STS either alone or in combination with chemotherapy or targeted therapy. The PD-1 receptor is present within the tumor microenvironment, and limits the activity of infiltrating cytotoxic T lymphocytes, thus blocking effective immune responses. The action of PD-1 is triggered upon binding to its ligands. PD-1 can stimulate the immunosuppressive function of regulatory T cells. Moreover, blockade of PD-1 can stimulate anti-tumor immune responses. Significant responses have been obtained in several sarcomas with acceptable tolerance. Preliminary clinical experience suggests that immunotherapy can be efficient in refractory leiomyosarcomas. Several drugs targeting the PD-1/PD-L1/2 axis are ongoing either as single agents or in combination with ipilimumab, kinase inhibitors, or chemotherapy in STS subtypes. Combination of radiotherapy with immunotherapy is included as a means of increasing tumor antigen release in metastatic STS. Immunomodulated SBRT is a particularly attractive strategy, given the potential of radiation to induce cytotoxicity in tumors and induce abscopal effects. A phase II radiation trial showed increased apoptosis-, intra-tumoral dendritic cells and accumulation of intratumoral T cells in STS with correlation with tumor-specific immune responses. We here propose a randomized phase II study to prolong progression-free survival (PFS) with the combination of SBRT/immunotherapy in oligometastatic STS patients. SBRT is well-tolerated with hardly any severe toxicity (fewer than 5% acute and late grade 3 toxicities). It is performed in an ambulatory setting in only a few treatment fractions. Associations between irradiation and immunomodulatory agents appear to be synergistic and show favorable tolerance profiles. Immunomodulatory agents have a more favorable toxicity profile than cytotoxic agents with about 65% overall acute toxicities. Immunotherapy selectively binds to PD-L1 and competitively blocks its interaction with PD-1. Compared with anti-PD-1 antibodies that target T-cells, immunotherapy targets tumor cells, and is therefore may induce fewer side effects, including a lower risk of autoimmune-related safety issues, as blockade of PD-L1 leaves the PD-L2 - PD-1 pathway intact to promote peripheral self-tolerance. Stereotactic irradiation is associated with an excellent tolerance with rates of grade 3 or more toxicities below 5%. Preliminary data of toxicity with the association of stereotactic irradiation and immunotherapy show no cumulative toxicity in association with immunotherapy. However, their incidence and characteristics are no different from that observed with stereotactic irradiation alone. Moreover, intracranial metastases are exceptional in sarcomas. The toxicity of the association for extracranial stereotactic irradiation does not seem to be increased either.
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Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
CLCC INSTITUT GUSTAVE ROUSSY C�cile LE PECHOUX En recrutement IDF 17/02/2024 14:52:00  Contacter
Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Centre Antoine LACASSAGNE - Nice - France Esma SAADA-BOUZID, MD En recrutement Contact (sur clinicalTrials)
Centre Eugene MARQUIS - Rennes - France Mohamed BENCHALAL, MD Recrutement non commencé Contact (sur clinicalTrials)
Centre François BACLESSE - Caen - France Juliette THARIAT, MD Recrutement non commencé Contact (sur clinicalTrials)
Centre Georges François LECLERC - Dijon - France David THIBOUW, MD Recrutement non commencé Contact (sur clinicalTrials)
Centre Henri BECQUEREL - Rouen - France Ovidiu VERESEZAN, MD Recrutement non commencé Contact (sur clinicalTrials)
Centre Oscar LAMBRET - Lille - France Abel CORDOBA LARGO, MD Recrutement non commencé Contact (sur clinicalTrials)
Institut Claudius REGAUD - Toulouse - France Anne DUCASSOU, MD Recrutement non commencé Contact (sur clinicalTrials)
Institut de Cancérologie de Lorraine - Vandœuvre-lès-Nancy - France Maria JOLNEROVSKI, MD Recrutement non commencé Contact (sur clinicalTrials)
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
AP-HM CHU La Timone - Marseille - France Active, sans recrutement Contact (sur clinicalTrials)
APHP La Pitié - Paris - France Aurore VOZY, MD Recrutement non commencé Contact (sur clinicalTrials)
Centre Léon BERARD - Lyon - France Marie Pierre SUNYACH, MD Recrutement non commencé Contact (sur clinicalTrials)
CHU de Poitiers - Poitiers - France Active, sans recrutement Contact (sur clinicalTrials)
Institut Bergonié - Bordeaux - France Pauline GILLON, MD En recrutement Contact (sur clinicalTrials)
Institut de cancérologie de Montpellier - Montpellier - France En recrutement Contact (sur clinicalTrials)
Institut de cancérologie Strasbourg Europe - Strasbourg - France Clara LEFEVRE En recrutement Contact (sur clinicalTrials)
Institut Paoli CALMETTES - Marseille - France Morgane GUENOLE, MD Recrutement non commencé Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- • STS (leiomyosarcomas uterine/extra-uterine, liposarcomas, undifferentiated
sarcomas), any grade

- Progressive disease according to RECIST 1.1 criteria,

- Metastatic disease (1-5 synchronous macroscopic metastases by chest and
abdominopelvic CT, maximal cumulated diameter 10 cm); any anatomic site

- First or second metastatic line

- Be ≥ 18 years of age on day of signing informed consent.

- Have a performance status of 0 or 1 on the ECOG Performance Scale.

- Have at least one lesion mesurable by RECIST 1.1 for irradiation with a size of
< 5 cm.

- Demonstrate adequate organ function: Absolute neutrophil count (ANC) ≥1,500
/mcL; Platelets ≥100,000 / mcL; Hemoglobin ≥9 g/dL or ≥5.6 mmol/L; Serum
creatinine ≤1.5 X upper limit of normal (ULN) OR measured or calculated
creatinine clearance (GFR can also be used in place of creatinine or CrCl) ≥50
mL/min for subject with creatinine levels > 1.5 X institutional ULN; Serum
total bilirubin ≤ 1.5 X ULN OR Direct bilirubin ≤ ULN for subjects with total
bilirubin levels > 1.5 ULN; AST (SGOT) and ALT (SGPT) ≤ 2.5 X ULN OR ≤ 5 X ULN
for subjects with liver metastases. All screening labs should be performed
within 15 days of treatment initiation.

- Female subjects of childbearing potential should have a negative urine or serum
pregnancy test within 72 hours prior to receiving the first dose of study
medication. If the urine test is positive or cannot be confirmed as negative, a
serum pregnancy test will be required. Female subjects of childbearing
potential should be willing to use 2 methods of birth control or be surgically
sterile, or abstain from heterosexual activity for the course of the study
through 120 days after the last dose of study medication. Subjects of
childbearing potential are those who have not been surgically sterilized or
have not been free from menses for > 1 year. Male subjects should agree to use
an adequate method of contraception starting with the first dose of study
therapy through 120 days after the last dose of study therapy.

- Surgical ablation (or other ablative methods such as thermal ablative methods)
remains possible if needed before SBRT, at least 4 weeks before randomisation
and provided that at least one lesion needs to be treated by SBRT.

- FFPE Tumor tissue collected before SBRT is available for immunohistochemistry
(optional)

- Archival metastatic biopsy blocks (or slides) on paraffin embedded samples
available. If no archival material is available, a fresh biopsy should be
performed if possible.

- Be willing and able to provide written informed consent/assent for the trial.

- affiliated with a health insurance system.


- Is currently participating in, or has participated in, a study of an investigational
agent or using an investigational device within 4 weeks prior to randomisation.

- Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior to the first dose of
trial treatment.

- Has had a prior monoclonal antibody within 4 weeks prior to randomisation or has not
recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents
administered more than 4 weeks earlier.

- Has had prior chemotherapy or targeted small molecule therapy within 4 weeks prior
to randomisation or who has not recovered (i.e. ≤ Grade 1 or at baseline) from
adverse events due to a previously administered agent (Subjects with ≤ Grade 2
neuropathy are an exception to this criterion and may qualify for the study). If
subjects received major surgery, they must have recovered adequately from the
toxicity and/or complications from the intervention prior to starting therapy.

- Have had previous radical radiation to any tumour site within 4 weeks prior to
randomisation

- Have had previous ablative treatment within 4 weeks prior to randomisation
(radiofrequency, surgery)

- Has a tumour within 5 mm of the spinal cord (owing to rare reported cases of
flare-up after initiation of immunotherapy)

- Has a known additional malignancy that is progressing or requires active treatment.
Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the
skin, or in situ cervical cancer that has undergone potentially curative therapy.

- Has an active autoimmune disease requiring systemic treatment within the past 3
months or a documented history of clinically severe autoimmune disease, or a
syndrome that requires systemic steroids or immunosuppressive agents. Subjects with
vitiligo or resolved childhood asthma/atopy would be an exception to this rule.
Subjects that require intermittent use of bronchodilators or local steroid
injections would not be excluded from the study. Subjects with hypothyroidism stable
on hormone replacement or Sjögren's syndrome will not be excluded from the study.

- Has evidence of symptomatic interstitial lung disease or an active, non-infectious
pneumonitis.

- Has an active infection requiring systemic therapy.

- Has a history or current evidence of any condition, therapy, or laboratory
abnormality that might confound the results of the trial, interfere with the
subject's participation for the full duration of the trial, or is not in the best
interest of the subject to participate, in the opinion of the treating investigator.

- Has known psychiatric or substance-abuse disorders that would interfere with
cooperation with the requirements of the trial.

- Is pregnant or breastfeeding, or expecting to conceive within the projected duration
of the trial, starting with the pre-screening or screening visit through 120 days
after the last dose of trial treatment.

- Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or
anti-Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody (including
ipilimumab or any other antibody or drug specifically targeting T-cell
co-stimulation or checkpoint pathways).

- Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).

- Has known active Hepatitis B (e.g. HBsAg reactive) or Hepatitis C (e.g. HCV RNA
[qualitative] is detected).

- Has received a live vaccine within 30 days prior to the first dose of trial
treatment.

- Has had major surgery or major blood transfusions (>3 packed cells) in the past 3
months.

- Receives IL-2, interferon or other non-study immunotherapy regimens; cytotoxic
chemotherapy; immunosuppressive agents; other investigational therapies; or chronic
use of systemic corticosteroids (used in the management of cancer or
non-cancer-related illnesses)

- Under-age patients

- Patients unable to express their consent

- Vulnerable persons as defined by article L1121-5 - 8:

- Pregnant women, women in labor or breast-feeding mothers, persons deprived of their
freedom by judicial or administrative decision, persons hospitalized without their
consent by virtue of articles L. 3212-1 and L. 3213-1 and who are not subject to the
provisions of article L. 1121-8

- Persons admitted to a social or health facility for reasons other than research

- Adults subject to a legal protection order or unable to give their consent