Informations générales (source: ClinicalTrials.gov)
A Phase III Randomized Trial of Post-operative Adjuvant Nivolumab and Concomitant Chemo-radiotherapy in High-risk Patients With Resected Squamous Cell Carcinoma of Head and Neck (NIVOPOSTOP)
Interventional
Phase 3
Groupe Oncologie Radiotherapie Tete et Cou (Voir sur ClinicalTrials)
octobre 2018
septembre 2027
19 octobre 2024
The purpose of this study is to determine the efficacy of nivolumab + cisplatin-RT
relative to standard of care (SOC) cisplatin-RT alone, using the disease-free survival
(DFS by investigator imaging assessment) as primary endpoint )
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT CURIE | 04/09/2024 13:49:47 | Contact (sur clinicalTrials) | |||
| CLCC INSTITUT GUSTAVE ROUSSY | Yun Gan TAO | 16/04/2024 12:02:54 | Contact (sur clinicalTrials) | ||
| CLCC RENE HUGUENIN INSTITUT CURIE | 04/09/2024 13:49:31 | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
1. Age > 18 and < 75 years
2. Performance Status (PS) ECOG 0-1 (Appendix 2)
3. Written informed consent
4. Recording of alcohol consumption and smoking history
5. Histologically proven squamous cell carcinoma of the head and neck from one or more
of the following primary sites: oral cavity, oropharynx, hypopharynx or larynx
6. Squamous cell carcinoma of the head and neck treated by primary surgery
7. Histopathological classification: pStage III or IV. However, Oropharyngeal Cancer
pStage II p16 positive with pT3N1 or pT4N1 and tobacco consumption ≥20 packs/year
are eligible. (American Joint Committee on Cancer 8th edition)
8. Subject must have complete macroscopic resection.
9. Subject must be free of disease
10. Recovery from the surgical procedure allowing for cisplatin-Radiotherapy
11. Radiotherapy planned to start within 4 to 9 weeks after surgery. However, a maximum
of 1 additional week could be considered in case of delay due to healing or
logistical problem
12. Patient/tumor carrying a high risk of relapse with:
- Extra-capsular extension (ECE),
- Multiple peri-neural invasion
- Multiple nodal extension without ECE (≥ 4 nodes)
- Positive margins (R1 or close margin ≤ 1 mm) R1 is microscopic residual disease
and close margin is R0 with a minimum margin ≤ 1 mm in any direction.
13. Adequate tumor specimen from archived or resected tissue available for PD-L1, TILs
and immune landscape and other biomarker evaluation
14. For oropharyngeal tumor, known p16 status (by IHC)
15. Patient's ability to receive cisplatin 100 mg/m2 for 3 cycles:
- Creatinine Cclearance (CrCl) ≥ 60 mL/min (measured or calculated by Cockcroft
and Gault method) or estimated Glomerular Filtration Rate (eGFR) ≥ 60
mL/min/1.73m2 (determined by CKDEPI or MDRD method). The highest value should
be considered if both are assessed.
- Absolute neutrophil count ≥1 500/mm3, platelets ≥100 000/mm3, haemoglobin ≥ 9
g/dL, aspartate transaminase (AST) and alanine transaminase (ALT) less than 2.5
times the upper limit of the normal range (ULN), total bilirubin ≤ 1.5
mg/dL(except Gilbert Syndrom: < 3.0 mg/dL).
- Peripheral neuropathy ≤ grade 1
- No hearing loss (assessed clinically and confirmed by audiogram if doubtful)
- Cardiac function compatible with hyperhydration
- No administration of prophylactic phenytoin
- Patients aged 71-74 years,must be fit according to geriatric evaluation
1. Age > 18 and < 75 years
2. Performance Status (PS) ECOG 0-1 (Appendix 2)
3. Written informed consent
4. Recording of alcohol consumption and smoking history
5. Histologically proven squamous cell carcinoma of the head and neck from one or more
of the following primary sites: oral cavity, oropharynx, hypopharynx or larynx
6. Squamous cell carcinoma of the head and neck treated by primary surgery
7. Histopathological classification: pStage III or IV. However, Oropharyngeal Cancer
pStage II p16 positive with pT3N1 or pT4N1 and tobacco consumption ≥20 packs/year
are eligible. (American Joint Committee on Cancer 8th edition)
8. Subject must have complete macroscopic resection.
9. Subject must be free of disease
10. Recovery from the surgical procedure allowing for cisplatin-Radiotherapy
11. Radiotherapy planned to start within 4 to 9 weeks after surgery. However, a maximum
of 1 additional week could be considered in case of delay due to healing or
logistical problem
12. Patient/tumor carrying a high risk of relapse with:
- Extra-capsular extension (ECE),
- Multiple peri-neural invasion
- Multiple nodal extension without ECE (≥ 4 nodes)
- Positive margins (R1 or close margin ≤ 1 mm) R1 is microscopic residual disease
and close margin is R0 with a minimum margin ≤ 1 mm in any direction.
13. Adequate tumor specimen from archived or resected tissue available for PD-L1, TILs
and immune landscape and other biomarker evaluation
14. For oropharyngeal tumor, known p16 status (by IHC)
15. Patient's ability to receive cisplatin 100 mg/m2 for 3 cycles:
- Creatinine Cclearance (CrCl) ≥ 60 mL/min (measured or calculated by Cockcroft
and Gault method) or estimated Glomerular Filtration Rate (eGFR) ≥ 60
mL/min/1.73m2 (determined by CKDEPI or MDRD method). The highest value should
be considered if both are assessed.
- Absolute neutrophil count ≥1 500/mm3, platelets ≥100 000/mm3, haemoglobin ≥ 9
g/dL, aspartate transaminase (AST) and alanine transaminase (ALT) less than 2.5
times the upper limit of the normal range (ULN), total bilirubin ≤ 1.5
mg/dL(except Gilbert Syndrom: < 3.0 mg/dL).
- Peripheral neuropathy ≤ grade 1
- No hearing loss (assessed clinically and confirmed by audiogram if doubtful)
- Cardiac function compatible with hyperhydration
- No administration of prophylactic phenytoin
- Patients aged 71-74 years,must be fit according to geriatric evaluation
1. Nasopharyngeal, paranasal sinuses, nasal cavity tumours or thyroid cancers
2. Squamous cell carcinoma involving cervical neck nodes with unknown primary site
3. Metastatic disease
4. Incomplete macroscopic resection (R2), as stated in the surgical report
5. Known active viral infection Human Immunodeficiency Virus (HIV), Hepatitis B/C) or
known history of positive test for HIV, active autoimmune disease and/or an active
immunodeficiency or ongoing immunosuppressive therapy
6. Active Central Nervous System disease
7. Interstitial lung disease
8. Active infection
9. Any prior treatment for the current head and neck cancer other than primary surgery.
This will include but is not limited to: prior tyrosine kinase inhibitors, any
monoclonal antibody, induction chemotherapy, prior RT, or use of any investigational
agent
10. Concurrent treatment with any other systemic anti-cancer therapy that is not
specified in the protocol
11. Concomitant treatment with any drug on the prohibited medication list such as live
vaccines. Live vaccines administered more than 30 days before study entry are
permitted
12. History of other malignancy within the last 3 years (exception of in situ carcinoma,
thyroid papillary carcinoma, skin carcinomas, localized prostate carcinoma Gleason 6
and in situ breast carcinoma)
13. Pregnant, breastfeeding patients, and female patients of childbearing potential who
are unwilling or unable to use 2 highly effective methods of contraception as
outlined in the protocol for the duration of the study and for at least 6 months
after the last dose of cisplatin and 5 months after the last dose of nivolumab
14. Male patients who are unwilling or unable to use contraception methods for the
duration of the study and for at least 6 months after the last dose of cisplatin.
15. Severe acute or chronic medical conditions including colitis, pneumonitis, pulmonary
fibrosis, laboratory abnormalities or other significant disease which, in the
judgment of the investigator, as a result of the medical interview, physical
examinations, or screening investigations would make the patient inappropriate for
entry into the trial
16. Known hypersensitivity to study drugs
17. Prior organ transplantation including allogenic stem-cell transplantation
18. Clinically significant (i.e., active) cardiovascular disease: cerebral vascular
accident/stroke (< 6 months prior to enrollment), myocardial infarction (< 6 months
prior to enrollment), unstable angina, congestive heart failure (≥ New York Heart
Association Classification Class II), or serious cardiac arrhythmia requiring
medication
19. Concurrent enrolment in another clinical trial using an investigational anti-cancer
treatment within 28 days prior to the first dose of study treatment
20. Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (e.g., infectious disease) illness
21. Any psychiatric condition (including active suicidal ideation), or psychological, or
familial, or sociological or geographical condition potentially hampering compliance
with the study protocol and follow-up schedule
22. Individuals deprived of liberty or placed under the authority of a tutor.