Informations générales (source: ClinicalTrials.gov)
Consitution Of A Biological Collection From Samples From The Gut Microbiote In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine
Observational
Hospices Civils de Lyon (Voir sur ClinicalTrials)
juillet 2018
juillet 2024
27 juillet 2024
Optimal surgical therapy (debridement in chronic osteomyelitis; device exchange in
patients with chronic prosthetic joint infection [PJI]) could be sometimes non-feasible,
especially in the elderly population. Therefore, a medical therapy with oral prolonged
suppressive antibiotic therapy (PSAT) seems to be an option to prevent recurrence and
prosthesis loosening. Unfortunately, some patients are infected with resistant pathogens
for which oral antibiotics are not suitable. Subcutaneous (SC) administration of
injectable intravenous antibiotics as PSAT could be a convenient way to limit
catheter-related complications and facilitate ambulatory care.
However, there are few data concerning the development of resistance under subcutaneous
prolonged treatment with betalactamine.
The aim of this study is is just to constitute a biological collection from samples from
the GUT microbiote in patients having a bone or joint infection treated by a suppressive
subcutaneous antibiotherapy with betalactamine. Later analysis will be led on those
samples to detect the acquisition of resistance or not.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hospices Civils de Lyon - 69004 - Lyon - France | Eugenie Mabrut, CRA | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients having an ostéo-articular infection (on material or on native bone) and
having an indication of antibiotic treatment suppressive subcutaneous by
betalactamine and managed at the Croix-Rousse Hospital
- Patients not opposed to participate to the study
- Patients having an ostéo-articular infection (on material or on native bone) and
having an indication of antibiotic treatment suppressive subcutaneous by
betalactamine and managed at the Croix-Rousse Hospital
- Patients not opposed to participate to the study
- none