Informations générales (source: ClinicalTrials.gov)
Biological Bank for Studies Related to Atrial Fibrillation and Stroke (BAFA)
Observational
Hospices Civils de Lyon (Voir sur ClinicalTrials)
avril 2018
avril 2029
25 octobre 2024
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical
practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes
on people over 65 years.
According to studies, 30 to 40% of isolated atrial fibrillations could be familial.
Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been
identified as potentially involved. Studies have identified genes common to the risk of
atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has
been intensively and extensively studied for almost a century, there are still many
questions. The pathophysiology is not sufficiently understood to allow finding more
effective therapies. It is necessary to identify genetic determinants and thus
potentially new pharmacological targets more adapted.
The establishment of a biological database will test hypotheses concerning the genetic
origin and thromboembolic process of atrial fibrillation and associated stroke.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service de médecine gériatrique Centre hospitalier Lyon Sud, Groupement hospitalier Sud - 69495 - Pierre-Bénite - France | Thomas GILBERT, Dr | Contact (sur clinicalTrials) | |||
| Service de rythmologie, hôpital cardiologique Louis Pradel - 69677 - Bron - France | Philippe CHEVALIER, PU-PH | Contact (sur clinicalTrials) | |||
| Service d'urgences Neurovasculaires - service de neurologie vasculaire , Hôpital Pierre Wertheimer - 69677 - Bron - France | Laura MECHTOUFF, PH | Contact (sur clinicalTrials) | |||
| Service neurologie Centre hospitalier Fleyriat - 01000 - Bourg-en-Bresse - France | Frédéric PHILIPPEAU, PH | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hôpital des charpennes - 69100 - Villeurbanne - France | Pierre Krolak-Salmon, PU,PH | Contact (sur clinicalTrials) | |||
Critères
Tous
Group 1a
- Inclusion Criteria :
- AF history
- Exclusion Criteria :
- No AF history
- patient who didn't signed consent
Group 1b
- Inclusion Criteria :
- AF history
- Scheduled electrophysiological exploration or AF ablation
- Exclusion Criteria :
- No AF history
- pregnant women
- patient who didn't signed consent
Group 1c
- Inclusion Criteria :
- AF/AT history
- Stroke history
- Exclusion Criteria :
- No Stroke history
- patient who didn't signed consent
Group 2
- Inclusion Criteria :
- patient over 80
- ECG: sinusal rhythm
- TTE : no left atrial dilatation
- Exclusion Criteria :
- atrial fibrillation history
- TTE : Left atria >25cm², > 34m/m2), FEVG < 50%
- ECG : QRS > 90 ms
- cardiac pathologies (excepted hypertension and valvulopathies)
- History of stroke and transient ischemic attack
- patient who didn't signed consent
Group 3
- Inclusion Criteria :
- cryptogenic stroke or transient ischemic attack history before 50 yo
- No AF history
- Exclusion Criteria :
- AF history
- stroke or transient ischemic attack over 50 yo
- patient who didn't signed consent
- Inclusion Criteria :
- AF history
- Exclusion Criteria :
- No AF history
- patient who didn't signed consent
Group 1b
- Inclusion Criteria :
- AF history
- Scheduled electrophysiological exploration or AF ablation
- Exclusion Criteria :
- No AF history
- pregnant women
- patient who didn't signed consent
Group 1c
- Inclusion Criteria :
- AF/AT history
- Stroke history
- Exclusion Criteria :
- No Stroke history
- patient who didn't signed consent
Group 2
- Inclusion Criteria :
- patient over 80
- ECG: sinusal rhythm
- TTE : no left atrial dilatation
- Exclusion Criteria :
- atrial fibrillation history
- TTE : Left atria >25cm², > 34m/m2), FEVG < 50%
- ECG : QRS > 90 ms
- cardiac pathologies (excepted hypertension and valvulopathies)
- History of stroke and transient ischemic attack
- patient who didn't signed consent
Group 3
- Inclusion Criteria :
- cryptogenic stroke or transient ischemic attack history before 50 yo
- No AF history
- Exclusion Criteria :
- AF history
- stroke or transient ischemic attack over 50 yo
- patient who didn't signed consent