Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT03630692 Statut inconnu

Titre

Safety and Compliance of Patients Treated With Oral Route Anti Cancer Drugs. (TOPTACOS)

Type

Observational

Pathologie

Néphrocarcinome
Tumeurs du rein

Phase

Promoteur

Institut Cancerologie de l'Ouest (Voir sur ClinicalTrials)

Date de début

mars 2016

Date de fin

juin 2020

Dernière mise à jour

29 juin 2024

Résumé

Generally, in the trials, an observant patient is described as correctly taking 90 to 100% of the prescribed doses. Here, the 80% compliance rate will be the cut-off between observant and non-observant patients. The evaluation methodology is based primarily on a survey of patients with metastatic or locally advanced kidney cancer who have just began an oral treatment protocol. The constitution of this cohort will be made from newly treated patients included by oncologists. The survey consists of implementing a series of questionnaires with each patient of the sample throughout the course of oral cancer care. This series of questionnaires will aim to identify: - the gradient of compliance of the patient with his treatment, - all the factors likely to influence positively or negatively the latter, whether medical, material or socio-economic, - the evolution of patient compliance during their treatment course, - a patient's quality of life index through the standardized quality of life survey form (EORTC - Quality of Life Questionnaire QLQ C30 version 3). - These questionnaires will be supplemented by the medical record data (including information on tolerance and possible drug interactions). The representativeness of the patients surveyed will be established by comparing the statistical characteristics of the surveyed population with those of the aggregate anonymous global data obtained by the two Medical Department of the French Regional Health Insurance of the two regions. From the data compiled by this study, different econometric models of patient behavior will seek to establish, in particular, a relationship between the probability that a given patient will be either non or poorly observant and the various variables proved to be statistically significant.

Détail

Voir le détail Data obtained from patients via the questionnaires will be copied into a computer database and as follows : - The date of birth (day, month and year), - Sex, - The patient's opinion and attitude towards the current treatment: compliance, adverse effects, lifestyle restrictions, changes in professional activity, family activities, relationships, physical fitness, moral, concomitant treatments, expenses not refunded parallels related to the management of adverse effects, - The family situation, the number of children, - Degrees obtained and employment, - Net monthly income. In parallel with the questionnaires, the Clinical Research Associate (CRAs) of the Observatory will collect data from the medical file on site. The data collected on an electronic Case Report Form (e-CRF) are as follows: - Type of cancer, date of diagnosis and metastatic disease, possible surgery and radiotherapy, - Description of the different treatment lines: number of cures, start and end date, response, toxicities, - Status of the patient at the end of the study. The number of subjects needed is calculated from observant patients. Based on the existing literature on adherence to chemotherapy or targeted oral therapy, the observed compliance rate is approximately 80%. However, since this characteristic is the object of this study and therefore not known ex ante, in the calculations of the sample size, the value allowing to obtain the lowest margin of error on the rate of compliance, an estimated prevalence of 50% compliance is used. By setting the risk of the first species at 5%, a confidence level of 95%, it is then necessary to include 132 patients. In addition, given the difficulty inherent in the questionnaires in collecting all the information, 20% of the data was estimated not to be evaluable. It will therefore be necessary to include 158 patients in the study to reach our goal. Fermer le détail

Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Centre Eugène Marquis - 35042 - Rennes - France	Laguerre Brigitte, MD	En recrutement	Contact (sur clinicalTrials)
Centre Hospitalier - 35403 - Saint-Malo - France	Desclos herve, MD	En recrutement	Contact (sur clinicalTrials)
CHIC Quimper - 29107 - Quimper - France	Schlürmann Friedricke, MD	En recrutement	Contact (sur clinicalTrials)
CHP - 35768 - Saint Grégoire - France	Artignan Xavier, MD	En recrutement	Contact (sur clinicalTrials)
CHU - 49933 - Angers - France	Bigot Pierre, MD	En recrutement	Contact (sur clinicalTrials)
Clinique Mutualiste de l'Estuaire - 44606 - Saint-Nazaire - France	Deguiral Philippe, MD	En recrutement	Contact (sur clinicalTrials)
Clinique Pasteur Saint Esprit - 29000 - Brest - France	Hasbini Ali, MD	En recrutement	Contact (sur clinicalTrials)
Institut de Cancérologie de l'Ouest - 49000 - Angers - France	Abadie-Lacourtoisie Sophie, MD	En recrutement	Contact (sur clinicalTrials)
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Centre Catherine de Sienne - 44000 - Nantes - France	El Kouri Claude, MD	En recrutement	Contact (sur clinicalTrials)
Centre Hospitalier - 72000 - Le Mans - France	Cojocarasu Oana, MD	En recrutement	Contact (sur clinicalTrials)
CHD Vendée - 85925 - La Roche-sur-Yon - France	L'Haridon Tifenn, MD	En recrutement	Contact (sur clinicalTrials)
CHP Océane - 56000 - Vannes - France	Monpetit Erik, MD	En recrutement	Contact (sur clinicalTrials)
CHU Morvan - 29609 - Brest - France	Schlürmann Friedricke, MD	En recrutement	Contact (sur clinicalTrials)
Clinique Victor Hugo - 72000 - Le mans - France	Voog Eric, MD	En recrutement	Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion Criteria:

- Adult patient

- Patient with metastatic or locally advanced kidney cancer

- Patient initiating for the first time an oral route anticancer drug : Sutent®
(sunitinib), Nexavar® (sorafenib), Afinitor® (everolimus), Votrient® (pazopanib) and
Inlyta® (axitinib) and Cabometyx® (cabozantinib)

- Patient having signed an informed consent

- Patient treated outside interventional clinical trial

Critère de non inclusion

- Patient with cancer other than kidney cancer

- Patient with non-extensive kidney cancer

- Patient treated by surgery, radiotherapy and intravenous chemotherapy exclusively

- Patient unable to undergo protocol monitoring

- Patient included in an interventional trial

- Patient refusing a survey at home or having hearing problems

- Other medical conditions that may interfere with the understanding of the informed
consent document, with the assessment of tolerance and the response to
questionnaires

- Patient with another condition deemed incompatible with the patient's inclusion into
the protocol.

- Patient under guardianship or trusteeship, deprived of liberty, underage patient or
pregnant woman

- Patient not affiliated with a social security system beneficiary of such a scheme

NCT03630692 - Safety and Compliance of Patients Treated With Oral Route Anti Cancer Drugs. (TOPTACOS)

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