Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT03644732 En recrutement IDF

Titre

Atlas of Human Cognition by SEEG (MAPCOG-SEEG)

Type

Observational

Pathologie

Épilepsie pharmacorésistante
Épilepsie
Épilepsies partielles

Phase

Promoteur

University Hospital, Grenoble (Voir sur ClinicalTrials)

Date de début

avril 2018

Date de fin

septembre 2030

Dernière mise à jour

29 juin 2024

Résumé

The main objective of MAPCOG_SEEG is to create a database including brain recordings of cognition performed in clinical routine in patients during the pre-surgical SEEG assessment. This aims to be able to propose the first atlas of human cognition with a high temporal and spatial resolution.

Détail

Voir le détail The pre-surgical assessment of a cortectomy in patient suffering from a refractory epilepsy includes several examinations aiming both, to specify the epileptogenic zone (EZ) which must be resected and to evaluate functional and cognitive risks of surgery. Nevertheless, in some patients, non-invasive evaluation does not give formal answer. In these subjects, it is then necessary to carry out a second step, consisting of an invasive exploration by implantation of intracerebral electrodes during a Stereoelectroencephalography (SEEG). Due to its temporal and spatial resolution, the SEEG allows, besides the precise determination of the EZ, to carry out a functional mapping of the cortical regions likely to be included in cortectomy. Conventionally, this mapping is carried out on the basis of the cortical electrical stimulations applied to the implanted electrodes. If this approach is very robust for exploring primary functions such as motor skills or language, it cannot be used to evaluate more complex cognitive tasks such as face recognition or attention. Essential cognitive tasks on a daily basis. This has led to the development in recent years, in Grenoble, of a complementary approach to cerebral stimulation: Dynamic Spectral Imaging (ISD). Numerous experimental paradigms have demonstrated that the realization of a cognitive task associates with the generation within the cortical regions involved in its treatment of a particular cortical activity. This activity is characterized by oscillations of the cortical rhythm in high frequencies (> 40 Hz), called gamma activities. The ISD thus consists in mapping this gamma activity during various cognitive tasks, thus making it possible to study more widely the complexity of the cognitive functions. MAPCOG_SEEG aims to collect the cerebral recording of the patients who have performed this cognitive exploration to be able to in fine propose an Atlas of human cognition which takes advantage of the very rich information in terms of spatial and temporal resolution of the SEEG. Furthermore, it will exactly allow more to understand the impact of the epilepsy and the surgery of the epilepsy on the cognition. Fermer le détail

Etablissements

Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
GHU PARIS PSY ET NEUROSCIENCES	Philippe DOMENECH	En recrutement IDF	Contact (sur clinicalTrials)
Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
University Hospital, Grenoble - 38043 - Grenoble - France	Philippe Kahane, MD/PhD	En recrutement	Contact (sur clinicalTrials)
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHRU Nancy - Nancy - France	Louis MAILLARD	En recrutement	Contact (sur clinicalTrials)
CHU Rennes - Rennes - France	Anca NICA	En recrutement	Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion Criteria:

- Drug-resistant focal epilepsy

- Justified SEEG exploration in the context of presurgical assessment of epilepsy

- Written non-opposition to study participation

- Intellectual capacities compatible with the compliance in the cognitive tasks

Critère de non inclusion

- Major Patient undergoing a legal protection measure or patient deprived of liberty
as a result of a judicial or administrative decision

- Impossibility of collecting information on exposure (recent arrival in France,
foreign language, etc.)

- Pregnant women (Contraindication to SEEG exploration)

NCT03644732 - Atlas of Human Cognition by SEEG (MAPCOG-SEEG)

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