Informations générales (source: ClinicalTrials.gov)
Investigation of Clinical, Cognitive and Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders (NeuroSplitsz)
Interventional
N/A
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
février 2019
février 2027
20 août 2024
The current diagnostic criteria for schizophrenia and other psychotic disorders are
relatively broad and lack precision. Therefore, distinct diseases may be grouped together
under the same diagnostic category, although these diseases may differ according to their
clinical expression, prognosis and perhaps their physiopathological causes.
We think that identifying subforms of psychotic disorders that are more homogeneous will
better enable to understand their respective physiopathological causes and find
personalized treatments.
This study will compare two subforms of psychotic disorders that have been clinically
distinguished in the 1970s. These phenotypes have however not been validated yet using
scientific investigations.
Using clinical assessments, cognitive evaluations and neurophysiological measures (fMRI)
investigating the domains of affect and psychomotoricity , we expect that these two
subforms will differ on their clinical, cognitive and neurophysiological characteristics,
namely: hebephrenia will be associated with deficits on the affect markers , and respect
psychomotoricity (catatonia scales, tests assessing movement planification) whereas the
opposite pattern will be observed for periodic catatonia.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service de Psychiatrie I, Hôpital Civil, Hôpitaux Universitaires de Strasbourg - 67091 - Strasbourg - France | Fabrice BERNA, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- for both patients and controls
- male or female willing to participate and who have signed up the legal document
- under the protection of health insurance for patients only
- schizophrenia or schizo-affective disorder according to the DSM-5 criteria
- periodic catatonia or hebephrenia accordin to WKL classification
- clinically stable for at least 2 months
- in or out patients for controls only
- no psychiatric history
- for both patients and controls
- male or female willing to participate and who have signed up the legal document
- under the protection of health insurance for patients only
- schizophrenia or schizo-affective disorder according to the DSM-5 criteria
- periodic catatonia or hebephrenia accordin to WKL classification
- clinically stable for at least 2 months
- in or out patients for controls only
- no psychiatric history
- for both patients and controls
- current severe or unstable somatic illness
- neurological history (epilepsia, brain injury, brain surgery...)
- current substance use disorder (DSM-5)
- current major depressive disorder (DSM-5)
- mental retardation (IQ < 70)
- pregnancy, breast feeding
- current legal control
- contra-indication for fMRI for controls only psychotropic intake during the last 3
weeks