Informations générales (source: ClinicalTrials.gov)
Radiological Study of the Hemodynamic Changes in the Aorta and Its Branches Before and After Endovascular Treatment of the Aortic Dissection (4DAo)
Interventional
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
mars 2019
novembre 2025
31 octobre 2024
Aortic dissection (AD) is a serious pathology affecting one person for 300 000 habitants
per year. In case of complicated AD on the descending aorta, it is necessary to perform
an endovascular surgery in association with medical treatment. An endoprosthesis is
implanted on the descending thoracic aorta in order to close the main intimal tear. This
closure lead to an increase in the thoracic true lumen diameter, a decrease in the
thoracic false lumen diameter, a better perfusion of the aortic branches. Furthermore,
even in case of open surgical treatment of the ascending aorta it can be necessary to
perform an endovascular treatment on the descending aorta, either to prevent and treat
aneurysmal evolution or to treat patent malperfusion syndrome.
CT and Magnetic Resonance angiography, by the realization of an aortic morphologic
evaluation, are the two key imaging exams in the DA. Nevertheless, CT can't provide
aortic dynamic evaluation, contrary to MRI. This exam, thanks to the phase-contrast
sequence can measure velocity and flow data in vessels, including aorta but also true and
false lumen in the AD. Thus, by verifying the perfusion of the aortic true lumen and the
aortic branches it is possible to perform an early evaluation of the endovascular
treatment of the DA.
Actually, only one study has realized an aortic dynamic evaluation on the AD,
unfortunately this study was limited to non-operated patients.
In order to assess the place of MRI in the AD, the ingestigation propose to determine if
phase-contrast MRI is able to evaluate the impact of the endovascular treatment on the
hemodynamic state of the aorta and its branches.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hopital Louis Pradel - Bron - France | Benoit Cosset, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients with an aortic dissection requiring endovascular treatment
- The endovascular treatment will be indicated according to the guidelines after
medical, radiological and surgical multidisciplinary discussion in our hospital.
- Patients that have signed the informed consent form.
- Members of a social protection scheme.
- Patients with an aortic dissection requiring endovascular treatment
- The endovascular treatment will be indicated according to the guidelines after
medical, radiological and surgical multidisciplinary discussion in our hospital.
- Patients that have signed the informed consent form.
- Members of a social protection scheme.
- Patients with an aortic dissection requiring an emergency intervention
- Patients with a contra-indication to endovascular treatment
- Contra-indication to MRI: claustrophobia, ferromagnetic materials: pacemaker,
prosthetic heart valve, implantable cardioverter defibrillators, vascular clip
- Pregnancy
- Breastfeeding
- Dementia
- Patients under guardianship
- Patients with difficulty in understanding the French language