Informations générales (source: ClinicalTrials.gov)
Primary Dependence to Analgesic Drugs: Development of a Predictive Approach Based on Early Modifications of Drug Use in the Ambulatory Care Setting (NEO-ADDICT)
Observational
University Hospital, Toulouse (Voir sur ClinicalTrials)
juin 2019
avril 2023
03 août 2024
Abuse of analgesics represents an important part of prescription drug abuse. The
consequences in terms of morbidity and mortality at the population level could reach
worryingly high levels, as illustrated by the US context. This issue should not focus
only on opioid analgesics, but must also account for some antiepileptics or
antidepressants with abuse potential (for example, pregabalin or gabapentin). In France,
reports related to tramadol abuse are increasing, in particular since dextropropoxyphene
withdrawal. Trends of growing abuse are also reported for other analgesics. Patients with
no history of primary dependence constituted a significant proportion of those developing
a tramadol abuse. There is therefore a need for early identification of these patients
and to raise awareness of health professionals on this issue, in particular in primary
care. Given the extensive use of analgesic drugs in France, the problem of primary
dependence should not be neglected. Since it will affect people who have no history of
drug abuse, strategies for identification and prevention are differing from a population
already using psychotropic products for example.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| University Hospital toulouse - Toulouse - France | Maryse Lapeyre-Mestre, MD PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Subjects included in the SNIIRAM (French National inter-scheme health insurance
information system) database
- Age >18 at index date (date of first analgesic dispensing)
- At least three dispensing of analgesic drugs
- At least two years of available follow-up at the date of first analgesic dispensing
in the SNIIRAM database
- No dispensing for any of the analgesics of interest in the past 12 months (selection
of new users only)
- Subjects included in the SNIIRAM (French National inter-scheme health insurance
information system) database
- Age >18 at index date (date of first analgesic dispensing)
- At least three dispensing of analgesic drugs
- At least two years of available follow-up at the date of first analgesic dispensing
in the SNIIRAM database
- No dispensing for any of the analgesics of interest in the past 12 months (selection
of new users only)
- none