Informations générales (source: ClinicalTrials.gov)
Feasibility Study of Uterine Transplantation from Living Donors in Terms of Efficacy and Safety in Patients with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)
Interventional
N/A
Hopital Foch (Voir sur ClinicalTrials)
décembre 2017
décembre 2034
05 avril 2025
In France, one in 4500 women is affected by the MayerRokitantskyKüsterHauser (MRKH)
syndrome which is characterized by the absence of uterus at birth. Currently, the only
solutions for these patients are:
- Gestational surrogacy, prohibited in France
- Adoption
- Resignation
Uterine transplantation could become a good alternative.
This study is conducted in 10 patients with MRKH type I syndrome, who will be
transplanted from a living donor uterus
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | Jean-Marc Ayoubi, MD PhD | vendredi 11 mars 2022 | Contact (sur clinicalTrials) | ||
Critères
Femme
Inclusion Criteria:
Graft recipient is a patient with Mayer-Rokitansky-Küster-Hauser Type I Uterine Vaginal
Agenesis (without renal, cardiac and bone malformations):
- Being aged between 18 and 38 years old
- In stable couple, with a pregnancy project, favorable psychological evaluation
- No history of cancer and transfusion
The living donor is a woman related to the Graft recipient with
- Absence of comorbidity (neurological, nephro-urological pathology, infectious,
psychiatric or psychological pathology)
- Absence of uterine surgery, abdomino-pelvic major pathology history
Graft recipient is a patient with Mayer-Rokitansky-Küster-Hauser Type I Uterine Vaginal
Agenesis (without renal, cardiac and bone malformations):
- Being aged between 18 and 38 years old
- In stable couple, with a pregnancy project, favorable psychological evaluation
- No history of cancer and transfusion
The living donor is a woman related to the Graft recipient with
- Absence of comorbidity (neurological, nephro-urological pathology, infectious,
psychiatric or psychological pathology)
- Absence of uterine surgery, abdomino-pelvic major pathology history
Graft recipient:
- Extreme oligo-astheno-spermia and azoospermia in the husband
- History of abdominopelvic surgery excluding uncomplicated appendectomy; vaginal
residue not allowing anastomosis
Living donor :
- Known thromboembolic risk factor
- No Compatibility with the recipient (group, rhesus, HLA)