Informations générales (source: ClinicalTrials.gov)
DEPREDICT: Clinical and Neurobiological Profile Predictive of Pejorative Outcome of Depression (DEPREDICT)
Interventional
N/A
Rennes University Hospital (Voir sur ClinicalTrials)
novembre 2019
janvier 2024
29 juin 2024
Depression is a frequent disease which can be marked by therapeutic resistance. It is
described as one of the most disabling disease with high cost for society. World Health
Organization pointed out that 350 million people are suffering from depression in the
world. This pathology is considered underdiagnosed, with inadequate care resources and
stigmatization.
There is a wide range of evidence in current literature that anxiety is one of the most
important factors involved in biological mechanism of treatment resistance in depression.
To date, there is a lack of knowledge on this topic. A better understanding of the role
of anxiety in the maintenance of depressive state will allow to i) identify quickly and
more accurately patients at risk of pejorative evolution and ii) develop specific
therapeutics targeting this dimension which remain badly controlled with actual
therapeutics.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CH Guillaume Regnier - 35000 - Rennes - France | Jean-Marie BATAIL | Contact (sur clinicalTrials) | |||
| CH Saint-Malo - 35400 - Saint-Malo - France | Anne-Marie Hemery, MD | Contact (sur clinicalTrials) | |||
| CHU de Brest - Hôpital de Bohars - 29820 - Brest - France | Michel Walter, MD | Contact (sur clinicalTrials) | |||
| CHU de Nantes - Hotel-Dieu - 44000 - Nantes - France | Samuel Bulteau, MD | Contact (sur clinicalTrials) | |||
| CHU de Tours, Clinique Psychiatrique Universitaire - 37044 - Tours - France | Wissam EL HAGE, MD | Contact (sur clinicalTrials) | |||
| EPSM du Morbihan - 56896 - Saint-Avé - France | François-Alexis Richard, MD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CH Henri Laborit - 86021 - Poitiers - France | Pr. Nemat Jaafari, MD | Contact (sur clinicalTrials) | |||
| CHU angers - 49933 - Angers - France | Bénédicte Gohier, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Men and women older than 18 years-old;
- Suffering from a Mood Depressive Episode ( according to DSM IV criteria), and-or
Mood Depressive recurrent depression (unipolar or bipolar) (<at stage 3 of Thase and
Rush). Treatment resistance will be assessed using Thase an Rush Classification and
measured with Maudsley Staging Method (Fekadu et al., 2009);
- MADRS score 15;
- Capacity for the patient to receive information on protocol;
- Patient who gave their consent to the protocol.
- Men and women older than 18 years-old;
- Suffering from a Mood Depressive Episode ( according to DSM IV criteria), and-or
Mood Depressive recurrent depression (unipolar or bipolar) (<at stage 3 of Thase and
Rush). Treatment resistance will be assessed using Thase an Rush Classification and
measured with Maudsley Staging Method (Fekadu et al., 2009);
- MADRS score 15;
- Capacity for the patient to receive information on protocol;
- Patient who gave their consent to the protocol.
- Contra-indication to MRI
- Patients under social protection or hospitalized without their consent
- Patients suffering from a psychiatric comorbidity such as: schizophrenia,
schizo-affective disorder, personality disorder, actual addiction, anorexia-bulimia,
obsessive-compulsive disorder;
- Patients suffering from severe intercurrent disease with health prognosis engaged;
- Patients suffering from neurological comorbidity such as: any neurodegenerative
disorder (Alzheimer disease, Parkinson disease, Lewy's body disease, multiple
sclerosis), any intracranial expansive process.
- Patients with an history of severe cranial injury (with coma);
- Patients with abnormal cerebral MRI.