Informations générales (source: ClinicalTrials.gov)
Papillomavirus Load in Rheumatic Inflammatory Diseases (PAPLOR)
Interventional
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
janvier 2020
janvier 2024
29 juin 2024
Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common chronic
inflammatory rheumatism, with a prevalence in the French population of 0.3% and 0.4%,
according to the criteria European League Against Rheumatism / American College of
Rheumatology (EULAR / ACR) 2010 and Assessemnt of SpondyloArthritis International Society
(ASAS) 2009 respectively. In patients whose pathology is resistant to first-line
treatment, such as methotrexate for rheumatoid arthritis and peripheral
spondyloarthritis, or non-steroidal anti-inflammatory drugs for axial spondyloarthritis,
the treatment is based on biotherapies, such as anti-inflammatory drugs. -TNF, to obtain
effective control of the disease and prevent joint damage.
Human papillomavirus (HPV) infection, the leading risk factor for cervical carcinoma, is
the most common sexually transmitted infection (STI) with a particularly high prevalence
among young women.
In addition, anti-TNF, used in the treatment of RA and SpA, and anti-IL6 receptor, used
in that of RA, could have opposite effects on HPV-dependent oncogenesis.
Thus, patients with RA or SpA may have a higher risk than the general population of
progression to cervical cytological abnormalities. Evaluation of the chronic carriage of
HPV would then be a useful tool in the management of these patients.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Centre Hospitalier Lyon Sud, Hospices Civils de Lyon - 69 495 - Pierre-Bénite - France | Fabienne Coury-lucas, MD | Contact (sur clinicalTrials) | |||
| Department of obstetrics, Femme Mère Enfant Hospital, Lyon, France - 69677 - Bron - France | Gery Lamblin, MD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hopital Edouard Herriot - service de rhumatologie - 69003 - Lyon - France | Emmanuelle VIGNOT, MD | Contact (sur clinicalTrials) | |||
Critères
Femme
Inclusion Criteria:
- Woman between 18 and 65 years old
- Patient with rheumatoid arthritis as defined in 2010 ACR/EULAR criteria or with
spondyloarthritis as defined in 2009 ASAS criteria
- Patient able to understand the objectives of the study and give documented informed
consent
- Patient affiliated to a social security scheme
- Woman between 18 and 65 years old
- Patient with rheumatoid arthritis as defined in 2010 ACR/EULAR criteria or with
spondyloarthritis as defined in 2009 ASAS criteria
- Patient able to understand the objectives of the study and give documented informed
consent
- Patient affiliated to a social security scheme
- Pregnant or breastfeeding patient
- Patient with a history of cervical cancer
- Patient under juridical protection
- Patient unable to provide informed consent due to linguistic or psychic impairment