Informations générales (source: ClinicalTrials.gov)
Diagnostic Accuracy of the Central Venous Pressure (CVP) Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients (VPVC)
Observational
University Hospital, Lille (Voir sur ClinicalTrials)
mars 2019
février 2021
29 juin 2024
Volume expansion (VE) is often administered in intensive care (ICU)-patient to improve
arterial oxygen delivery. Such effect is secondary to an increase in stroke volume and
cardiac output. However, cardiac output increase in response to VE (fluid responsiveness)
only occurs when the heart is preload-dependant. Increasing evidence of the deleterious
effects of inappropriate fluid administration encourages the development of variables
predicting fluid responsiveness, but few have been validated in spontaneously breathing
patients.
Central venous pressure (CVP) variation in spontaneously patients during standardized or
unstandardized inspiratory maneuver may represent an easy tool to predict fluid
responsiveness. The hypothesise is that inspiratory maneuver may increase CVP variation
in fluid responsiveness patient whereas no or few variation may reflect fluid
unresponsiveness.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hôpital Roger Salengro, CHU - Lille - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria
- Spontaneous breathing without mechanical assistance
- Central venous catheter (superior vena cava) and monitoring of central venous
pressure
- Urinary catheter and monitoring of intra-abdominal pressure
Exclusion Criteria:
- Intolerance to ventilatory manœuvre including Severe basal dyspnea/Symptomatic heart
failure (pulmonary edema)
- Contraindication to passive leg raising (intracranial hypertension)
- Passive leg raising unsuitable for measuring hemodynamic response : High grade
aortic insufficiency/ Poor echogenicity unsuitable to measure the velocity-time
/integral of aortic blood flow/ Pregnancy/Abdominal hypertension with abdominal
compartment syndrome/ Lower leg amputation
- Necessity of urgent hemodynamic therapy (within 90 min)
- Modification of hemodynamic therapy during study protocol (vascular filling,
increase catecholamine dose
- Spontaneous breathing without mechanical assistance
- Central venous catheter (superior vena cava) and monitoring of central venous
pressure
- Urinary catheter and monitoring of intra-abdominal pressure
Exclusion Criteria:
- Intolerance to ventilatory manœuvre including Severe basal dyspnea/Symptomatic heart
failure (pulmonary edema)
- Contraindication to passive leg raising (intracranial hypertension)
- Passive leg raising unsuitable for measuring hemodynamic response : High grade
aortic insufficiency/ Poor echogenicity unsuitable to measure the velocity-time
/integral of aortic blood flow/ Pregnancy/Abdominal hypertension with abdominal
compartment syndrome/ Lower leg amputation
- Necessity of urgent hemodynamic therapy (within 90 min)
- Modification of hemodynamic therapy during study protocol (vascular filling,
increase catecholamine dose