Informations générales (source: ClinicalTrials.gov)
Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients. A Prospective, Multicentric, Randomized, Controlled Trial. (PRECI-Surg)
Interventional
N/A
University Hospital, Lille (Voir sur ClinicalTrials)
juin 2019
juin 2024
29 juin 2024
In patients with type 2 diabetes, Roux-en-Y gastric bypass (RYGB), which excludes a
portion of the stomach and the proximal intestine from the alimentary circuit, improves
glucose metabolism more rapidly and more extensively than is expected from weight loss.
The mechanisms of this unique effect of gastrointestinal exclusion appear to be complex
and have not yet been clarified. A recent study unveil that intestinal uptake of ingested
glucose is diminished by RYGB and restricted to the common limb, where food meets bile
and other digestive fluids, resulting in an overall decrease of post prandial blood
glucose excursion. the hypothesize that reducing the length of the common limb, which is
rarely measured and highly variable in clinical practice, may significantly affect the
metabolic outcome of gastrointestinal surgical procedures. The aim of the present study
is to compare the impact of two variants of Roux-en-Y gastric bypass with a short common
limb, the long alimentary limb or the long biliary limb Roux-en-Y gastric bypass, on type
2 diabetes remission in severely obese patients.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Ch de Valenciennes - Valenciennes - France | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Ch Boulogne-Sur-Me - 62321 - Boulogne Sur Mer - France | Contact (sur clinicalTrials) | ||||
| Chu Amiens Picardie - Amiens - France | Contact (sur clinicalTrials) | ||||
| Hop Claude Huriez Chu Lille - 59037 - Lille - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- BMI ≥ 35 kg/m2
- All patient with type 2 diabetes
- Patients who were candidates for obesity surgery in accordance with French
recommendation
- BMI ≥ 35 kg/m2
- All patient with type 2 diabetes
- Patients who were candidates for obesity surgery in accordance with French
recommendation
- Severe cognitive or mental disorders
- patient who have already undergone obesity surgery
- Severe and non-stabilised eating disorders
- The likely inability of the patient to participate in lifelong medical follow-up
- Alcohol or psychoactive substances dependence
- The absence of identified prior medical management of obesity
- Diseases that are life-threatening in the short and medium term;
- Contraindications to general anaesthesia.