Informations générales (source: ClinicalTrials.gov)
Molecular Prognosis of Lymphomas of the Central Nervous System (ALYCE-molecular) (ALYCEmolecular)
Observational
Hospices Civils de Lyon (Voir sur ClinicalTrials)
janvier 2016
janvier 2020
29 juin 2024
Central nervous system lymphoma (PCNSL) is a diffuse large B cell lymphoma (DLBCL) entity
with a particularly poor prognosis (median survival less than 3 years). They are still
poorly characterized biologically, largely because of their rarity (300 cases / year in
France) and the difficulty for obtaining a material of sufficient quality and quantity.
It is nevertheless assumed that their pathophysiology is particular, since they develop
exclusively in an immunological sanctuary, and that they present some characteristic
molecular abnormalities (mutation of MYD88 or TBL1XR1 for example).
A collection of 74 PCNSLs has created, clinically annotated, from which frozen material
is available in addition to the material fixed and included in paraffin (cohort ALYCE).
Informed consent was gathered for all patients. Comparative Genomic Hybridization-array
analysis of this cohort has already revealed abnormalities associated with a poor
prognosis (unpublished data). The objective of this study is to complete this analysis by
sequencing a panel of 96 mutant genes recurrently in DLBCLs and PCNSLs, and the molecular
determination of the original cell by the (RT-MLPA) Reverse Transcriptase-Multiplex
Ligation-dependent Probe Amplification technique.
The integration of genetic, molecular and transcriptomic data may define prognostic
markers and open perspectives for translational research in PCNSL.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service d'hématologie biologique - Centre Hospitalier Lyon Sud - HCL - 69495 - Pierre-Bénite - France | Pierre SUJOBERT, Dr | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Adults
- With a lymphoma of the central nervous system
- Patients having signed the consent for the conservation of their samples within the
cohort
- Adults
- With a lymphoma of the central nervous system
- Patients having signed the consent for the conservation of their samples within the
cohort
- <18 old years
- Other diagnosis than lymphoma of the central nervous system
- No consent form signed