Informations générales (source: ClinicalTrials.gov)
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy. (EPIMEM)
Interventional
N/A
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
mars 2019
septembre 2027
31 juillet 2024
Age related focal epilepsies in children encompasses, according to the ILAE criteria,
benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy
(ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS).
These non structural epilepsies are associated with interictal sleep spike and waves
activated by sleep. Moreover, high prevalence of learning disorders occur in children
with age related epilepsies. A correlation is suspected between learning disorders and
sleep activation of spike and waves. The investigators suppose that learning dysfunction
is linked to loss of information during sleep of epileptic children, unlike for control
patients. As sleep allows memory consolidation of words learned during wakefulness, an
epileptic activity during sleep may disrupt this consolidation, leading to a loss of
information.
Hypothesis: the investigators hypothesize a disruption of memory consolidation after one
night in children affected with ABPE and ECSWS (severe group) compared to memory
consolidation in children affected with BECTS (benign group), and control group.
Primary purpose:
To demonstrate that the deficit of delayed recall in 15 word learning test after one
night is higher for the "severe group", compared to the "benign group" and the control
group.
Secondary purposes:
- to study the evolution over time of memory consolidation
- to evaluate the correlation of the deficit of delayed recall with executive
dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy,
and sleep architecture
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL PEDIATRIE REEDUCATION BULLION | Mathieu KUCHENBUCH, MD | Contact (sur clinicalTrials) | |||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hopital de Hautepierre-Service de Pediatrie/Neurologie - 67098 - Strasbourg - France | Anne DE SAINT MARTIN, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
Principal:
- normal psychomotor development
- informed consent signed by both parents and subject if able
- affiliated to social security regimen
Specific
Patients from "severe" and "benign" groups:
- focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
- children hospitalized for their follow-up
- normal neuroimaging
Control group
-children hospitalized for a non neurologic disease
Principal:
- normal psychomotor development
- informed consent signed by both parents and subject if able
- affiliated to social security regimen
Specific
Patients from "severe" and "benign" groups:
- focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
- children hospitalized for their follow-up
- normal neuroimaging
Control group
-children hospitalized for a non neurologic disease
Principal:
Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French
language Minor under care
Specific
Patients from "severe" and "benign" groups:
- degenerative disease
- abnormal neuroimaging
- mental deficiency
Control group
- neurologic trouble
- abnormal sleep EEG
- intellectual deficiency