Informations générales (source: ClinicalTrials.gov)
Evaluation of the Risk of Necrotizing Enterocolitis in Fetuses With Intrauterine Growth Restriction. (ECUN)
Observational
Hospices Civils de Lyon (Voir sur ClinicalTrials)
septembre 2018
avril 2019
29 juin 2024
Necrotizing enterocolitis is the most common gastroenterological emergency in
neonatology. Its mortality is high, ranging from 15 to 30%. Prematurity is the main risk
factor for necrotizing enterocolitis, as well as the very low birth weight (<1500 g)
associated with prematurity. Among the early neonatal complications of intrauterine
growth restriction neonates, necrotizing enterocolitis is frequently reported in the
literature. The situation of chronic hypoxia of these fetuses is at the origin of a
vascular redistribution favoring the cerebral circulation to the detriment of the
mesenteric vascularization, which could lead to the development of an necrotizing
enterocolitis. However, data from the literature concerning this over-risk of necrotizing
enterocolitis in the case of intrauterine growth restriction are discordant. The
heterogeneity of the definitions used for the intrauterine growth restriction and
diagnostic criteria for necrotizing enterocolitis from one study to another could explain
these discrepancies. The investigator's hypothesis is that the risk of necrotizing
enterocolitis is higher among newborns in intrauterine growth restriction compared to
control children.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hôpital Femme Mère Enfant - Bron - France | Muriel Doret, Prof. | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- All birth between 24 + 0 weeks of amenorrhea and 36 + 6 weeks of amenorrhea
- with isolated intrauterine growth restriction at the maternity ward of the hospital
Femme-Mère-Enfant
- from 1st of january 2011 to 31 december 2016.
Inclusion Criteria for control group:
- All birth between 24 + 0 weeks of amenorrhea and 36 + 6 weeks of amenorrhea
- without isolated intrauterine growth restriction at the maternity ward of the
hospital Femme-Mère-Enfant
- from 1st of january 2011 to 31 december 2016.
- All birth between 24 + 0 weeks of amenorrhea and 36 + 6 weeks of amenorrhea
- with isolated intrauterine growth restriction at the maternity ward of the hospital
Femme-Mère-Enfant
- from 1st of january 2011 to 31 december 2016.
Inclusion Criteria for control group:
- All birth between 24 + 0 weeks of amenorrhea and 36 + 6 weeks of amenorrhea
- without isolated intrauterine growth restriction at the maternity ward of the
hospital Femme-Mère-Enfant
- from 1st of january 2011 to 31 december 2016.
- Infants born out of the hospital and secondarily hospitalized in our department
- unaccompanied pregnancies
- multiple pregnancies
- children with malformations or genetic abnormalities,
- medical termination of pregnancy
- fetal deaths in utero