Informations générales (source: ClinicalTrials.gov)
French Registry for Monitoring Pregnancies and Children of Women With Multiple Sclerosis Within The Observatoire Français de la Sclérose en Plaque (OFSEP) Cohort
Observational [Patient Registry]
Hospices Civils de Lyon (Voir sur ClinicalTrials)
août 2019
août 2036
02 février 2026
The influence of pregnancy on the course of multiple sclerosis (MS) has long been a
controversial topic. After the publication of the first large prospective study of
pregnancy and MS in 1998, counselling of women with MS has radically changed and many
patients have been able to fulfill their desire of motherhood. However, there are still
some challenges for the neurologist, who has to face old unanswered questions or new
issues, regarding the use of disease modifying drugs (DMDs) in this period of life,
effects on the short and long term outcome of the mother (in terms of relapses and
disability) and the child, role of breast-feeding and locoregional analgesia.
To set up a national prospective pregnancy registry for patients with MS, nested within
the Observatoire Français de la Sclérose en Plaque (OFSEP) cohort, owing to a better
knowledge of interactions between MS and pregnancy-related issues (pregnancy itself,
locoregional analgesia, breastfeeding, impact of using or stopping DMDs on
women/children…)
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CENTRE HOSPITALIER SUD FRANCILIEN | POTTIER | 09/06/2024 11:48:13 | Contacter | ||
| HOPITAL FOCH | MAIA TCHIKVILADZE | 02/02/2026 08:25:46 | Contacter | ||
| HOPITAL FOCH | MAIA TCHIKVILADZE | 26/01/2026 08:40:46 | Contacter | ||
| HOPITAL FONDATION A. DE ROTHSCHILD | Caroline BENSA | 21/06/2024 13:32:59 | Contacter | ||
| HOPITAL NOVO | POTTIER | 18/09/2025 17:50:12 | Contacter | ||
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - Hôpital Henri Mondor-Albert Chenevier | Alain CREANGE | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital La Pitié-Salpêtrière | Elisabeth MAILLART | Contact (sur clinicalTrials) | |||
| CENTRE HOSPITALIER DE GONESSE | Eric MANCHON | Contact (sur clinicalTrials) | |||
| CH DE VERSAILLES SITE ANDRE MIGNOT | Chantal NIEFLE | Contact (sur clinicalTrials) | |||
| CHI POISSY ST-GERMAIN | Olivier HEINZLEF | Contact (sur clinicalTrials) | |||
| GH PARIS SITE SAINT JOSEPH | Hélène BRASME | Contact (sur clinicalTrials) | |||
| HOPITAL NOVO | Corinne DUPEL-POTTIER | Contact (sur clinicalTrials) | |||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Hospitalier Annecy Genevois - 74000 - Annecy 3037543 - France | Nathalie MOREL | Contact (sur clinicalTrials) | |||
| Centre Hospitalier d'Avignon - 84000 - Avignon 3035681 - France | Patricia TOURNAIRE | Contact (sur clinicalTrials) | |||
| Centre hospitalier Métropole Savoie - 73000 - Chambéry 3027422 - France | Clara GROSSET-JANIN | Contact (sur clinicalTrials) | |||
| Ch Epinal - 88000 - Épinal 3020035 - France | Evelyne PLANQUE | Contact (sur clinicalTrials) | |||
| Chr La Miletrie - 86021 - Poitiers 2986495 - France | Amélie DOS SANTO | Contact (sur clinicalTrials) | |||
| Chu de Grenoble - 38043 - Grenoble 3014728 - France | Olivier CASEZ | Contact (sur clinicalTrials) | |||
| Hôpital Central - 54035 - Nancy 2990999 - France | Guillaume MATHEY | Contact (sur clinicalTrials) | |||
| Hopital Du Bocage - 21079 - Dijon 3021372 - France | Thibault MOREAU | Contact (sur clinicalTrials) | |||
| Hopital Dupuytren - 87042 - Limoges 2998286 - France | Laurent MAGY | Contact (sur clinicalTrials) | |||
| Hopital G. Et R. Laennec - 44800 - Saint-Herblain 2979590 - France | David LAPLAUD | Contact (sur clinicalTrials) | |||
| Hopital Gui de Chauliac - 34295 - Montpellier 2992166 - France | Pierre LABAUGE | Contact (sur clinicalTrials) | |||
| Hopital Pasteur - 06001 - Nice 2990440 - France | Christine LEBRUN-FRENAY | Contact (sur clinicalTrials) | |||
| Hopital Purpan - 31059 - Toulouse 2972315 - France | Jonathan CIRON | Contact (sur clinicalTrials) | |||
| Hôpital St Vincent De Paul - 59020 - Lille 2998324 - France | Arnaud KWIATKOWSKI | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Cabinet médical Dr C. CORNUT-CHAUVINC - 69008 - Lyon 2996944 - France | Catherine CORNUT- CHAUVINC | Contact (sur clinicalTrials) | |||
| Cabinet médical Dr L. GUILLOTON - 69440 - Mornant 2991743 - France | Laurent GUILLOTON | Contact (sur clinicalTrials) | |||
| Cabinet médical Dr Philippe NEUSCHWANDER - 69006 - Lyon 2996944 - France | Philippe NEUSCHWANDER | Contact (sur clinicalTrials) | |||
| Centre Hospitalier de Saint-Denis - 93200 - Saint-Denis 2980916 - France | Thomas DEBROUCKER | Contact (sur clinicalTrials) | |||
| Centre Hospitalier Mémorial - 50009 - Saint-Lô 2978758 - France | Lydie DUBUC-LEPETIT | Contact (sur clinicalTrials) | |||
| Centre Hospitalier Saint Joseph Saint Luc - 69007 - Lyon 2996944 - France | Amandine BENOIT | Contact (sur clinicalTrials) | |||
| Chru de Lille - 59037 - Lille 2998324 - France | Hélène ZEPHIR | Contact (sur clinicalTrials) | |||
| Chru de Tours Hopital Bretonneau - 37044 - Tours 2972191 - France | Ines DOGHRI | Contact (sur clinicalTrials) | |||
| Chu D'Amiens - 80054 - Amiens 3037854 - France | Abdullatif AL KHEDR | Contact (sur clinicalTrials) | |||
| Fondation Rotschild - 75019 - Paris 2988507 - France | Caroline BENSA-KOSCHER | Contact (sur clinicalTrials) | |||
| Hopital Caremeau - 30029 - Nîmes 2990363 - France | Eric THOUVENOT | Contact (sur clinicalTrials) | |||
| Hôpital Charles-Nicolle - 76000 - Rouen 2982652 - France | Bertrand BOURRE | Contact (sur clinicalTrials) | |||
| Hopital Cote de Nacre - 14033 - Caen 3029241 - France | Pierre BRANGER | Contact (sur clinicalTrials) | |||
| Hôpital de Brive - 19100 - Brive-la-Gaillarde 3029974 - France | Alexis MONTCUQUET | Contact (sur clinicalTrials) | |||
| Hopital Gabriel Montpied - 63003 - Clermont-Ferrand 3024635 - France | Pierre CLAVELOU | Contact (sur clinicalTrials) | |||
| Hopital Hautepierre - 67098 - Strasbourg 2973783 - France | Jérôme DE SEZE | Contact (sur clinicalTrials) | |||
| Hopital Jean Minjoz - 25030 - Besançon 3033123 - France | Eric BERGER | Contact (sur clinicalTrials) | |||
| Hôpital national des Quinze-Vingt. - 75571 - Paris 2988507 - France | Dalia DIMITRI BOULOS | Contact (sur clinicalTrials) | |||
| Hôpital Neurologique Pierre Wertheimer - 69677 - Bron 3029931 - France | Sandra VUKUSIC | Contact (sur clinicalTrials) | |||
| Hopital Nord - 42277 - Saint-Priest-en-Jarez 2977350 - France | Jean-Philippe CAMDESSANCHE | Contact (sur clinicalTrials) | |||
| Hopital Pellegrin - 33076 - Bordeaux 3031582 - France | Aurélie RUET | Contact (sur clinicalTrials) | |||
| Hopital Pontchaillou - 35033 - Rennes 2983990 - France | Laure MICHEL | Contact (sur clinicalTrials) | |||
| Hôpital Raymond Poincaré - 92380 - Garches 3016675 - France | Ayman TOURBAH | Contact (sur clinicalTrials) | |||
| Hopital Timone Adultes - 13385 - Marseille 2995469 - France | Jean PELLETIER | Contact (sur clinicalTrials) | |||
| Médipôle Lyon Villeurbanne - 69100 - Villeurbanne 2968254 - France | Pékès CODJA | Contact (sur clinicalTrials) | |||
Critères
Tous
- All groups of patients eligible to participate to the Observatoire Français de la
Sclérose en Plaque (OFSEP), including :
- Definite Multiple sclerosis (MS) according to McDonald criteria
- Whatever the clinical course (single attack MS, relapsing-remitting MS, secondary
progressive MS, primary progressive MS)
- Radiologically Isolated Syndromes (RIS) (will be validated by the RIS expert group)
- Clinically Isolated Syndromes (CIS)
- Neuromyelitis optica (NMO) and NMO spectrum disorders (will be validated by the
"Neuro-optico-myélite aiguë de Devic et des syndromes neurologiques apparentés"
(NOMADMUS) expert group)
- No age limit (patients under the age of 18 might be included, provided informed
consent is obtained from the parents)
- Ongoing pregnancy: there will be no limit in the gestational age at inclusion. Women
can be included at any time before delivery, but the gestational age at inclusion
will be recorded and introduced in the analyses whenever pertinent. However,
neurologists and patients will be encouraged to start the study as soon as pregnancy
is diagnosed.
- Able to give informed consent
- Able to read and/or understand French
Exclusion Criteria:
- None