Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT03967769 Statut inconnu

Titre

Apneic Oxygénation by Nasal Canula During Infants Airway Management Study (Oxyeno)

Type

Interventional

Pathologie

Phase

N/A

Promoteur

University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)

Date de début

août 2019

Date de fin

novembre 2020

Dernière mise à jour

29 juin 2024

Résumé

This is a randomized clinical trial investigating the utility of apneic oxygenation via high flow nasal cannulae during airway management for infants general anaesthesia. Three groups will be compared, a control group at 0 L/min, a 0,2L/Kg/min and a 1L/Kg/min group. The primary outcome will be the time (in seconds) between onset of apnea and one of theses end-points : desaturation (SPO2 <95%) or Airway management completed.

Détail

Voir le détail Airway management can be a life saving therapy. One major complication that may occur during airway management is a lack of oxygen in the blood, especially in peadiatric population, due to anatomical and physiological considerations. If severe or prolonged, this lack of oxygen can result in permanent brain damage, damage to other vital organs or even death. Pre-oxygenation prior to induction of anaesthesia is standard practice to prevent desaturation and hypoxemia. Apnoeic oxygenation in adults is effective and prolongs the time to desaturation. Apneic oxygenation is a novel method of delivering oxygen to a patient despite a lack of active respiration (i.e. the patient is not breathing on their own and the investigators are not providing the patient an artificial breath). The simplest and least invasive method to provide apneic oxygenation is the application of oxygen through nasal cannula during airway management. The effectiveness of apnoeic oxygenation in the adult is well document, especially in bariatric population or ICU, however only few study are interesting about pediatric population. Recent studies suggest that high flow is similar to low flow oxygenotherapy. Therefore, the aim of this study was to investigate the effectiveness of apnoeic oxygenation during airway management in infants. This is a randomized clinical trial investigating the utility of apneic oxygenation via high flow nasal cannula during airway management for infant's general anesthesia. Three groups will be compared, a control group at 0 L/min, a 0,2L/Kg/min and a 1L/Kg/min group. The primary outcome will be the time (in seconds) between onset of apnea and one of these end-points : desaturation (SPO2 <95%) or Airway management completed. All infants included will receive french actual standard of care concerning general anesthesia and peri-operative medicine. Fermer le détail

Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU - Clermont-Ferrand - France	Adeline Gerst	En recrutement		Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion Criteria:

- Infants Between 0 (post-conceptionnal age >41 weeks post Amenorrhea) and 24 months
of life

- Scheduled for elective surgery under general anesthesia

- Need of orotracheal Intubation by direct laryngoscopy or Video-laryngoscopy

Critère de non inclusion

- Emergency surgery

- Crush Induction needed

- High clinical risk of difficult airway management

- Premature before 1 month of life

NCT03967769 - Apneic Oxygénation by Nasal Canula During Infants Airway Management Study (Oxyeno)

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Etablissements
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