Informations générales (source: ClinicalTrials.gov)
Evaluation of the Interest of Pulmonary Ultrasound in the Diagnosis and Early Detection of Acute Thoracic Syndrome in Hospitalized Children for Vaso-occlusive Sickle Cell Crisis: Multicenter Prospective Study (ECHO-STA)
Interventional
N/A
Centre Hospitalier Intercommunal Creteil (Voir sur ClinicalTrials)
avril 2019
juillet 2023
29 juin 2024
ATS (acute thoracic syndrome) refers to acute pulmonary involvement in a sickle cell
patient. The diagnosis is based on the association of clinical signs (fever or
respiratory symptoms) with a recent pulmonary infiltrate on the chest x-ray.
The main objective of the study is to evaluate the place of the pulmonary ultrasound for
the diagnosis of ATS, in comparison with frontal chest x-ray.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| AP-HP - Hôpital Armand Trousseau-La Roche Guyon | Guillaume Thouvenin, MD | Contact (sur clinicalTrials) | |||
| CHI DE CRETEIL | Fouad MADHI, MD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hôpital Antoine Béclère - 92141 - Clamart - France | Mélanie TAVEIRA, MD | Contact (sur clinicalTrials) | |||
| Hôpital Bicêtre - 94270 - Le Kremlin-Bicêtre - France | Irina CRAIU, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Age: ≥12 months and <18 years
- Has a major sickle cell disease whatever the genotype
- Admission to hospital for a febrile vaso-occlusive crisis (VOC) or not
- Evolving at home for less than 48h
- Concomitant treatment with hydroxycarbamide / hydroxyurea possible
- Signed consent
- Patients affiliated to a French social security scheme
- Age: ≥12 months and <18 years
- Has a major sickle cell disease whatever the genotype
- Admission to hospital for a febrile vaso-occlusive crisis (VOC) or not
- Evolving at home for less than 48h
- Concomitant treatment with hydroxycarbamide / hydroxyurea possible
- Signed consent
- Patients affiliated to a French social security scheme
- Child presenting an acute thoracic syndrome (ATS) from the outset at the admission
- Child who presented an ATS in the month preceding the inclusion
- Child in regular transfusion program or child who has received a hematopoietic stem
cell transplant
- Child hospitalized at least 5 times for VOC in the year preceding inclusion (psychic
problems making difficult the evaluation of the pain)
- Child who has already been included in the study during a previous VOC (each child
participates in the study only once)
- VOC evolving for more than 48 hours before admission to the emergency room
- Acute splenic sequestration crisis at admission