Informations générales (source: ClinicalTrials.gov)
Effect of the Quality of Dietary Proteins on the Sleep Young Elite Athletes and the Obese Adolescent (Protmorpheus)
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
novembre 2019
mars 2022
29 juin 2024
Adolescence is characterized by major transitions in sleep and circadian rhythm. This
rapid pivotal period increases the risks of sleep debt and poor sleep quality, leading to
pronounced diurnal fatigue and drowsiness . Some adolescent's populations are more
vulnerable than others to poor sleep. Obesity and elite sports involvement are two
factors that have been distinctly associated with disturbed sleep. Several studies show
that obesity was associated with a decrease in sleep efficiency and increased arousals .
On the other hand, recent studies point out that sleep problem is widespread in young
athletes which substantially increase the risks of injury, burnout and concussions .
Despite the importance of sleep in holistic development, physical (i.e. recovery,
metabolism, muscle growth, weight control), cognitive (i.e. learning, memory,
decision-making, Vigilance) and athletic performances (Fullagar et al., 2015).
A wide range of recent papers emphasize that some nutrients take part in the regulation
of internal clock and sleep quality. The effect of tryptophan (Trp) on sleep was lifted
on the basis of the serotonergic hypothesis. Serotonin (5-HT) is synthesized from Trp
circulating in the brain following two-step procedure in raphe neurons. Serotonin, in
turn, is a precursor of melatonin and both molecules contribute to the regulation of
sleep-wake behaviors. However, Trp is an essential amino acid, which means that it cannot
be synthesized by the organism, and must exclusively be provided via degradation of
proteins from the diet. The passage of tryptophan to the brain is assured through carrier
disposed at the blood-brain barrier level. However, carrier transport depends on other
competitive amino acids (LNAAs: leucine, isoleucine, valine, phenylalanine, and
tyrosine). Therefore, increased brain uptake of tryptophan does not depend only on Trp
concentrations but rather on the blood Trp / LNAA ratio.
PROTMORPHEUS trial, was designed to examine how supplementation with proteins of
different Trp/LNAA ratio affect sleep on adolescents (obese, athletes) with mild sleep
disturbances.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Clermont-Ferrand - 63000 - Clermont-Ferrand - France | Lise Laclautre | Contact (sur clinicalTrials) | |||
Critères
Homme
Inclusion Criteria:
- young athletes OR adolescent with BMI > 90 percentiles
- young athletes OR adolescent with BMI > 90 percentiles
- Disorders and / or pathology of sleep and chronic diseases of the digestive tract
- Medical or surgical history not compatible with the study, any other chronic illness
or injury that may interfere with the subject's abilities
- Take medication that may interfere with the results of the study (corticosteroids
...) or sleeping pills
- Surgical intervention in the previous 3 months
- Regular consumption of tobacco, cannabis or alcohol
- Special diet