Informations générales (source: ClinicalTrials.gov)
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Interventional
N/A
Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)
août 2019
août 2028
29 août 2025
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI
nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the
intervention group versus treatment by dental surgeons as part of their usual practice in
the control group.
For the intervention group, periodontal management will be carried out for a maximum of 6
months after randomisation, prolonged by a follow-up of 6 months including a maintenance
visit at M9.
All patients will have an FDG-PET at M0 and M12 for evaluation of inflammation on carotid
atherosclerotic plaques.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| AP-HP Assistance publique - Hôpitaux de Paris | 13/12/2025 07:54:10 | Contacter | |||
| AP-HP - Hôpital Bichat | |||||
| AP-HP - Hôpital Europeen Georges Pompidou | |||||
| AP-HP - Hôpital Lariboisiere-Fernand Widal | |||||
| AP-HP - Hôpital Saint Antoine | |||||
Critères
Tous
Inclusion Criteria:
- Patients hospitalized for an acute myocardial infarction and included in the
Frenchie registry
- Score ≥ 5 on the screening questionnaire for periodontitis
- Six teeth at least (excluding wisdom teeth)
- Consent signature
- Affiliation to a French medical insurance (Sécurité Sociale)
- Patients hospitalized for an acute myocardial infarction and included in the
Frenchie registry
- Score ≥ 5 on the screening questionnaire for periodontitis
- Six teeth at least (excluding wisdom teeth)
- Consent signature
- Affiliation to a French medical insurance (Sécurité Sociale)
- Patients with diseases,other than cardiovascular and diabetes, known to change the
periodontal state such as AIDS, rheumatoid arthritis, Chediak-Higashi syndrome,
Papillon-Lefèvre
- Systemic antibiotic therapy> 48 hours in the 3 months prior to inclusion
- Acute heart failure
- Uncontrolled ventricular rhythm disorders
- Impossibility for the patient to attend follow-up visits
- Impossibility to maintain the extended position for 20 minutes
- Immunosuppressive therapy> 1 month in the 6 months prior to inclusion
- Pregnancy, breastfeeding
- Known hypersensitivity to chlorhexidine, povidone, 18-fluoro-deoxyglucose