Informations générales (source: ClinicalTrials.gov)
Mastication Involvement in Postprandial Thermogenesis Via Autonomic Nervous System Activation in Normal Weight and Obese People (MASTICAL)
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
décembre 2018
décembre 2020
29 juin 2024
The objective of the study is to analyze the specific role of physical properties of food
and mastication in the cephalic phase reflex of thermogenesis, and the involvement of the
autonomic nervous system in the implementation of this reflex.
The hypothesis of the study is that oral stimulation elicited by food properties during
mastication can generate changes in the amplitude of variation of thermogenesis, and that
these changes are distinct from those attributable to the thermal effect of food during
digestion.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Clermont-Ferrand - 63003 - Clermont-Ferrand - Auvergne - France | Lise Laclautre | Contact (sur clinicalTrials) | |||
Critères
Homme
Inclusion criteria :
19 < body mass index < 25 kg/m2 for the normal weight group 30 < body mass index < 35
kg/m2 for the obese group Good general health
Exclusion criteria :
- sport activity
- Smoking in the 6 months before the beginning of the study
- Regular alcohol consumption (more than 4 unit/day)
- Medication that may interfere with the results of the study (beta-blockers,
corticoids, anti-inflammatories, thyroid hormone, insulin, antiarrhythmics) or that
may have an effect on salivation or muscular activity
- Oral or dental pathology (including pain), current oral care
- Orthodontic treatment in the 3 years before the study
- Weigh gain or weight loss of more than 10% in the 3 last months
- Thyroid disturbance
- High blood pressure
- Cardiac activity anomaly
- Anomaly for one of the biological elements : complete blood count, fasting blood
glucose, glycated haemoglobin, thyroid hormone (TSH), sedimentation rate > 8mm, CRP
rate > 10ml/L
- Allergies, intolerance or disgust for one of the food tested
19 < body mass index < 25 kg/m2 for the normal weight group 30 < body mass index < 35
kg/m2 for the obese group Good general health
Exclusion criteria :
- sport activity
- Smoking in the 6 months before the beginning of the study
- Regular alcohol consumption (more than 4 unit/day)
- Medication that may interfere with the results of the study (beta-blockers,
corticoids, anti-inflammatories, thyroid hormone, insulin, antiarrhythmics) or that
may have an effect on salivation or muscular activity
- Oral or dental pathology (including pain), current oral care
- Orthodontic treatment in the 3 years before the study
- Weigh gain or weight loss of more than 10% in the 3 last months
- Thyroid disturbance
- High blood pressure
- Cardiac activity anomaly
- Anomaly for one of the biological elements : complete blood count, fasting blood
glucose, glycated haemoglobin, thyroid hormone (TSH), sedimentation rate > 8mm, CRP
rate > 10ml/L
- Allergies, intolerance or disgust for one of the food tested