Informations générales (source: ClinicalTrials.gov)
Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging (CervIRM)
Observational
University Hospital, Angers (Voir sur ClinicalTrials)
novembre 2020
novembre 2022
29 juin 2024
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome
(PFS). This syndrome is due to a possible complication of surgical excision of a tumor of
the cerebellum (4th ventricle) and is characterized by transient postoperative mutism,
dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is
thought to be related to axonal lesions. The long-term consequences on the cognitive and
psychosocial sphere of PFS have been widely documented. On the other hand, the literature
concerning the consequences of this syndrome on language is much restricted. Beyond the
language, the role of cerebellum would be central in cognition, some authors even
comparing it to a great "conductor" who would underlie the learning of most motor and
cognitive automatisms.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Christelle DUFOUR | 15/04/2024 07:32:01 | Contacter | ||
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - Hôpital Necker-Enfants Malades | Stéphanie Puget, MD | Contact (sur clinicalTrials) | |||
| CLCC INSTITUT CURIE | François Doz, MD | Contact (sur clinicalTrials) | |||
| LES HOPITAUX DE SAINT MAURICE | Mathilde Chevignard, MD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CHU Angers - Angers - France | Mickaël DINOMAIS | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patient with a low grade glioma of the posterior fossa or a medulloblastoma
- Healthy volunteers without any tumor in the posterior fossa (control case)
- At one year of the last treatment for the retrospective groups, or patient who have
an indication to a surgery of a tumor of the posterior fossa
- Eligibility to a functional MRI
- Informed consent dated and signed by the holder of the parental authority (if minor)
or by the patient (if major) to take part in the study
- Affiliated to a Social Security scheme
- Patient with a low grade glioma of the posterior fossa or a medulloblastoma
- Healthy volunteers without any tumor in the posterior fossa (control case)
- At one year of the last treatment for the retrospective groups, or patient who have
an indication to a surgery of a tumor of the posterior fossa
- Eligibility to a functional MRI
- Informed consent dated and signed by the holder of the parental authority (if minor)
or by the patient (if major) to take part in the study
- Affiliated to a Social Security scheme
- Antecedent of neurologic, metabolic or genetic disease
- Brainstem glioma
- Have a contraindication to a MRI