Informations générales (source: ClinicalTrials.gov)

NCT04174820 Statut inconnu
Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging (CervIRM)
Observational
  • Médulloblastome
  • Tumeurs sous-tentorielles
University Hospital, Angers (Voir sur ClinicalTrials)
novembre 2020
novembre 2022
29 juin 2024
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.
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Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
CLCC INSTITUT GUSTAVE ROUSSY Christelle DUFOUR Active, sans recrutement 15/04/2024 07:32:01  Contacter
Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
AP-HP - Hôpital Necker-Enfants Malades Stéphanie Puget, MD Recrutement non commencé Contact (sur clinicalTrials)
CLCC INSTITUT CURIE François Doz, MD Recrutement non commencé Contact (sur clinicalTrials)
LES HOPITAUX DE SAINT MAURICE Mathilde Chevignard, MD Recrutement non commencé Contact (sur clinicalTrials)
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU Angers - Angers - France Mickaël DINOMAIS En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- Patient with a low grade glioma of the posterior fossa or a medulloblastoma

- Healthy volunteers without any tumor in the posterior fossa (control case)

- At one year of the last treatment for the retrospective groups, or patient who have
an indication to a surgery of a tumor of the posterior fossa

- Eligibility to a functional MRI

- Informed consent dated and signed by the holder of the parental authority (if minor)
or by the patient (if major) to take part in the study

- Affiliated to a Social Security scheme



- Antecedent of neurologic, metabolic or genetic disease

- Brainstem glioma

- Have a contraindication to a MRI