Informations générales (source: ClinicalTrials.gov)
Traumatic Long-term Memory of Pain - Pain Conditioning Study in Humans (TRAUMADOL)
Interventional
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
janvier 2021
février 2027
29 juin 2024
Few studies have focused on understanding the mechanisms underlying pain memory in
humans. Thus, this project aims to investigate the link between pain memorisation and
memorisation of the associated context by addressing the issue of pain conditioning. The
study is composed of two successive parts: one pilot then one experimental. The goal is
to understand pain memorisation processes by analysing the parallel between pain
memorisation and memorisation of a traumatic event. By using immersive virtual reality,
investigators aim to show that contextual pain conditioning is associated with : 1- a
specific neural networks; 2- a reactivation of vegetative and behavioural reactions
related to pain as well as electro-physiological markers when re-exposure to the specific
pain-conditioning-context; 3- an implicit hypermnesia of the pain-associated context and
a struggle to extinguish conditioning; 4- a favoured elaboration of false memories of the
contextual pain. The emitted hypothesis suggests that a cortical and behavioural mnemonic
trace is created during encoding of pain in association with its context, and that the
latter can reactivate although the pain itself has disappeared. This implicit cortical
mnemonic trace, evoked by the simple pain-associated context, could explain the notion of
pain print persisting at long-term in patients suffering from chronic pain.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hôpital Neurologique, - 69677 - Bron - France | Luis GARCIA-LARREA, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Healthy subject
- Subject between 18 and 50 years old
- Subjects having given their written consent
- Subjects with health insurance
- Healthy subject
- Subject between 18 and 50 years old
- Subjects having given their written consent
- Subjects with health insurance
- Prior addiction to drugs
- Prior neurological issues
- Chronic pain (neuropathic or non-neuropathic)
- Pregnant/breast-feeding women
- Absence of efficient contraception method for the duration of the study (1 month)
for participants of procreation age (no inclusion limitation for male participants
of procreation age)
- Subjects under chronic analgesic treatment or having taken an analgesic treatment in
the 24 h preceding the experiment
- Heart issues
- Subjects under justice surveillance
- Subjects participating in another study which inclusion period overlaps with the one
from this study