Informations générales (source: ClinicalTrials.gov)
Control of the Opening of mPTP by Ex Vivo Measurements on Permeabilized Muscle Fibers (COMMEF)
Observational
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
janvier 2020
février 2021
29 juin 2024
mPTP (Mitochondrial Permeability Transition Pore) is a channel formed by a protein
complex integrated into the inner membrane of mitochondria. Its opening is related to the
elevation of the intra-mitochondrial calcium concentration and will result in: a
mitochondrial decoupling, a rupture of the metabolic gradient and the release of
pro-apoptotic factors.
The objective of this study is the development of a new ex vivo technique for
characterizing mPTP by a dual measurement combining oxygraphy and fluorimetry on
permeabilized skeletal muscle fibers.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Clermont-Ferrand - 63000 - Clermont-Ferrand - France | Ruddy Richard | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients aged over 18 ;
- Patients referred for a knee ligamentoplasty (DIDT technique) ;
- Patients who signed the non-opposition form after being informed ;
- Patients benefiting from or affiliated to a social security.
- Patients aged over 18 ;
- Patients referred for a knee ligamentoplasty (DIDT technique) ;
- Patients who signed the non-opposition form after being informed ;
- Patients benefiting from or affiliated to a social security.
- Patients under guardianship, curatorship or deprived of liberty.