Informations générales (source: ClinicalTrials.gov)
Muscle Multi-parametric NMR Imaging Development in Aged People With Sarcopenia or Frailty Syndrome; CLINical Study (MIDAS)
Interventional
N/A
University Hospital, Bordeaux (Voir sur ClinicalTrials)
octobre 2019
mai 2022
29 juin 2024
Frailty is a multideterminant syndrome in which muscle function appears to play a central
role. Muscle function depends on brain control, nutrition and perfusion. We hypothesized
that multiparametric MRI assessment combined with comprehensive gerontological assessment
(CGA) and routine biological assessment of inflammation in a sample of older people with
and without diabetes will allow to explore on one side the possibilities of
multi-parametric MRI muscle and brain imaging to describe the correlates of frailty and
on the other side will describe the different muscle/brain alterations due to diabetes in
frailty.
The main objective is to compare the lipid percent of the rectus femoris in frail and
pre-frail older subjects and in non-frail older subjects.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service de gériatrie - CHU Bordeaux - hôpital Xavier Arnozan - 33604 - Pessac - France | Isabelle Bourdel-Marchasson, MD, PhD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Service de Médecine Gériatrique, CHU de LIMOGES - 87000 - Limoges - France | Achille THCALLA, MD,PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Robust or frail or pre-frail with at least 25% frail and 25% pre-frail according to
Frieds criteria
- Barthel index > or = 60/100
- With or without diabetes mellitus, 45 to 55 % with known diabetes mellitus
- With no contraindication to undergo an MRI examination
- Robust or frail or pre-frail with at least 25% frail and 25% pre-frail according to
Frieds criteria
- Barthel index > or = 60/100
- With or without diabetes mellitus, 45 to 55 % with known diabetes mellitus
- With no contraindication to undergo an MRI examination
- not willing to participate
- not able to give informed consent or to understand basic instruction due to any
problem (sensorial, educational, language)
- without social insurance
- with a legal protection
- with significant cognitive alteration (MMSe<21/30 or in case of low literacy <19/30)
- with a recent (2 month period) severe event: hospitalization, sepsis, stroke even
with complete recovery, trauma
- with stroke sequelae (motor, speech)