Informations générales (source: ClinicalTrials.gov)
Search for a Microbiotic Signature Associated With Periodontitis According to the Chicago Classification 2018 (PAROMIP)
Observational
Nantes University Hospital (Voir sur ClinicalTrials)
mai 2019
mars 2020
29 juin 2024
A new classification of periodontal diseases was created in 2018. the investigators want
to know if this clinical classification is based, or not, on a biological reality. To do
this, the investigators will collect data from the clinical examination (clinical
assessment and radiological assessment) as well as non-invasive samples of subgingival
plaque and crevicular gingival fluid (CGF). The subgingival plaque samples will be
analyzed to define the microbiotic profiles of the patients and the CGF determined to
define their inflammatory expression profiles. These results will then be linked to the
diagnosis of severity of periodontitis.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Nantes Universitary Hospital - 44093 - Nantes - Loire Atlantique - France | Assem Soueidan, PU-PH | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Men and women speaking and understanding French
- Aged over 18
- with generalized periodontitis (more than 30% of affected sites)
- Requiring non-surgical periodontal therapy
- with a minimum of 12 teeth (3 per quadrant), fitted or not
- Having given his oral consent to participate in the study
- Having given his written consent to participate in a biocollection
- Men and women speaking and understanding French
- Aged over 18
- with generalized periodontitis (more than 30% of affected sites)
- Requiring non-surgical periodontal therapy
- with a minimum of 12 teeth (3 per quadrant), fitted or not
- Having given his oral consent to participate in the study
- Having given his written consent to participate in a biocollection
- Less than 12 teeth present (3 teeth per quadrant)
- Presence of acute oral lesions (periodontal abscesses, endodontic abscesses,
infectious or mycotic lesions...)
- Presence of ulcerative-necrotic gingivitis or periodontitis
- Presence of endo-periodontal lesions
- Chronic or systemic pathology or treatment that can influence the periodontal
microbiota : immunotherapy, corticosteroid therapy, biotherapy, unbalanced diabetes,
acute inflammatory rheumatism, neurological impairment...
- Antibiotic during the 3 month preceding inclusion
- Psychological or linguistic disability preventing good understanding of the study
- Minors
- Major patients under legal protection
- Patients deprived of their liberty
- Pregnant or lactating woman
- Patient not affiliated to a health insurance scheme