Informations générales (source: ClinicalTrials.gov)
Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum (STADEH)
Interventional
N/A
Poitiers University Hospital (Voir sur ClinicalTrials)
octobre 2020
octobre 2023
29 juin 2024
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Clinical
studies have demonstrated a link between staphylococcal skin colonization and the
pathogenesis of AD, but the implication of bacterial virulence factors remains largely
uncharacterized. Finally, AD is often associated with herpes simplex skin infections. The
aim of this project is to investigate the role of staphylococcal toxins in the
exacerbation and maintenance of atopic skin inflammation and in the occurrence of
infectious complications such as eczema herpeticum.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Poitiers - Poitiers - France | Ewa HAINAUT | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CHU de Bordeaux - Bordeaux - France | Julien SENESCHAL | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients with moderate AD (SCORAD between 25 and 50) or severe AD (SCORAD> 50)
- Skin lesions in the forearms
- Free subject, without neither guardianship, wardship nor subordination
- Patient with Social Security
- Informed and signed consent by the patient after clear and loyal information on the
study
- Patients with moderate AD (SCORAD between 25 and 50) or severe AD (SCORAD> 50)
- Skin lesions in the forearms
- Free subject, without neither guardianship, wardship nor subordination
- Patient with Social Security
- Informed and signed consent by the patient after clear and loyal information on the
study
- Age < 18 year-old
- Patients with mild AD (SCORAD < 25)
- Patients without skin lesions in the forearms
- Patients treated with dermocorticoid or calcineurin inhibitor for less than two
weeks
- Patients under systemic treatment : Methotrexate, Ciclosporin, Mycophenolate
Mofetil, Azathioprine, general corticosteroids for less than 4 weeks
- Patients under biological treatment : Dupilumab for less than 5 half-lives
- Patient without Social Security
- Pregnant and nursing women