Informations générales (source: ClinicalTrials.gov)
High Resolution Imaging for Analysis of Multinodular and Vacuolating Neuronal Tumor of the Cerebrum (HAM)
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
mars 2020
mars 2028
29 juin 2024
MVNT (multinodular and vacuolating neuronal tumor of the cerebrum) is a benign, recently
discovered, neuronal lesion, the incidence of which is unknown.
It seems to predominate in the temporal lobes and presents a characteristic MRI
appearance: multiple subcortical nodules, developed at the white substance / gray
substance junction, of variable size, well limited, in iso-hyposignal T1, hypersignal T2
and hypersignal FLAIR.
The articles describing this entity report the lack of scalability in MRI during patient
monitoring, going in the direction of the benignity of the lesion.
The diagnosis sometimes remains uncertain with current MRI sequences, and the patient
risks undergoing invasive surgery to remove a lesion that is actually benign. Hence the
importance of developing the most precise diagnostic criteria possible. The contribution
of advanced MRI techniques, such as ultra-high resolution sequences in the
characterization of these lesions, has not yet been studied.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Augustin LECLER | 21/06/2024 13:32:59 | Contacter | ||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Hospitalier Lyon Sud - 69495 - Pierre Bénite - France | Contact (sur clinicalTrials) | ||||
| CHU de Rouen - 76000 - Rouen - France | Contact (sur clinicalTrials) | ||||
| CHU Rennes - 35033 - Rennes - France | Béatrice Carsin-Nicol, MD PhD | Contact (sur clinicalTrials) | |||
| Groupe Hospitalier Pellegrin - 33076 - Bordeaux - France | Contact (sur clinicalTrials) | ||||
| Hôpital Pierre Paul Riquet, CHU Purpan - 31059 - Toulouse - France | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hôpital Laennec - 44800 - Saint-Herblain - France | Jesus AGUILLAR, MD PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patient over 18 years of age
- Prospective inclusion of all patients with suspected MVNT on a first exploratory
MRI: at least the 2 major criteria associated with at least 1 minor criterion will
be required to fit into the definition of suspected MVNT:
- Major criteria :
- Multinomodular clustered appearance
- Franc hypersignal FLAIR/T2
- Minor criteria :
- No mass effect
- Hyposignal T1
- Having received informed information about the study and having given express
consent to participate in the study
- Patient over 18 years of age
- Prospective inclusion of all patients with suspected MVNT on a first exploratory
MRI: at least the 2 major criteria associated with at least 1 minor criterion will
be required to fit into the definition of suspected MVNT:
- Major criteria :
- Multinomodular clustered appearance
- Franc hypersignal FLAIR/T2
- Minor criteria :
- No mass effect
- Hyposignal T1
- Having received informed information about the study and having given express
consent to participate in the study
- Contraindication to MRI
- Patient benefiting from a legal protection measure
- Pregnant or breastfeeding woman
Secondary exclusion criteria:
- No characterization MRI done