Informations générales (source: ClinicalTrials.gov)
OP2C : Prialt® Observatory in Clinical Practice (OP2C)
Observational [Patient Registry]
Institut Cancerologie de l'Ouest (Voir sur ClinicalTrials)
juillet 2020
septembre 2027
19 juillet 2024
Ziconotide is a strong analgesic marketed since 2005 in Europe and reserved for the
intrathecal route. Its efficacy has been proven in particular by 3 randomized clinical
studies.
It is particularly effective on neuropathic pain and its main advantages are its power of
action, the absence of bone marrow toxicity, and the absence of respiratory depression.
In addition, there were no signs of withdrawal when stopping the drug, or of
tachyphylaxis.
However, during these studies many adverse reactions were highlighted, especially
neuropsychiatric which limited its use. This toxicity was mainly related to the
administration of too high doses, especially at the start of treatment (too fast
titration).
In recent years, the use of intrathecal ziconotide has become a pertinent option. Indeed,
it is recommended as first-line among the intrathecal treatment options.
However, there is a lack of data on the current use of ziconotide in current practice.
The objective of the study will be to describe the practical methods of using intrathecal
treatments containing ziconotide.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | NAOUFEL OUERCHEFANI | 05/05/2025 07:12:06 | Contacter | ||
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CLCC RENE HUGUENIN INSTITUT CURIE | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Hospitalier Departemental La Roche Sur Yon - 85000 - La Roche-sur-Yon - France | Yves Marie PLUCHON, MD | Contact (sur clinicalTrials) | |||
| Centre Leon Berard - 69008 - Lyon - France | Gisèle CHVETZOFF, MD | Contact (sur clinicalTrials) | |||
| CHU NICE - 06003 - Nice - France | Contact (sur clinicalTrials) | ||||
| Clinique Breteche - 44000 - Nantes - France | Contact (sur clinicalTrials) | ||||
| Institut de Cancerologie de L'Ouest - 49000 - Angers - France | DENIS DUPOIRON, MD | Contact (sur clinicalTrials) | |||
| Institut de Cancerologie de Montpellier - 34298 - Montpellier - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- Age ≥ 18 years old
- Severe refractory chronic pain requiring intrathecal analgesia
- Candidate for intrathecal analgesia treatment with ziconotide
- Patient informed about the study and agreeing to take part in.
- Age ≥ 18 years old
- Severe refractory chronic pain requiring intrathecal analgesia
- Candidate for intrathecal analgesia treatment with ziconotide
- Patient informed about the study and agreeing to take part in.
- Contraindications to ziconotide