Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT04326218 En recrutement IDF

Titre

Immunopathological Analysis in a French National Cohort of Membranous Nephropathy (IHMN)

Type

Interventional

Pathologie

Glomérulonéphrite extra-membraneuse

Phase

N/A

Promoteur

Centre Hospitalier Universitaire de Nice (Voir sur ClinicalTrials)

Date de début

juillet 2020

Date de fin

décembre 2031

Dernière mise à jour

24 juin 2026

Résumé

National cohort of all cases of membranous nephropathy (MN) during a 1 year period in France, based on a pathological and/or serological diagnostic, collecting the data on: - incidence of MN - prevalence of anti-PLA2R1 and anti-THSD7A - clinical outcome one year after diagnosis or after relapse (complete remission, partial remission or persistent nephrotic syndrome) - environmental risk factors for the onset of MN - HLA markers - patient care status in France

Détail

Voir le détail Membranous nephropathy is a rare auto-immune disease, yet a major cause of nephrotic syndrome in adults. It is characterised by the deposition of antigen-antibody complexes on the glomerular basement membrane, leading to a decreased filtration rate and eventually kidney failure. About one third of cases have a favourable outcome without any treatment, another third requires a long term symptomatic treatment to manage their symptoms, and the last third of patients advances to end stage renal failure, requiring dialysis and kidney graft. MN can be associated with cancer, infections, other auto-immune diseases and with certain drugs (secondary MN), but most often it is idiopathic. In the latter form two antigens have been identified, PLA2R1 and THSD7A, with corresponding auto-antibodies in 70% and 2% of MN patients, respectively. GWAS studies identified several alleles associated with a higher risk of developing MN, however, since these are common variants they cannot explain the onset of MN in the vast majority of cases. Since MN is a rare disease, the number of new cases per each center is low, and nation-wide studies are needed to correctly evaluate its incidence and risk factors for the onset of MN, as well as validate previously published findings in monocentric studies on the prognostic value of PLA2R1 epitope spreading (immunisation against multiple domains of PLA2R1). This study aims to establish a French national cohort of all cases of MN in a one year period in France. The inclusion will last one year with one additional year of follow-up, for a total of 2 years. In the first year, nephrologists of each associate centers in France will propose the study to each of their patients diagnosed with MN. In addition, clinical information will be collected, as well as a survey on patients' lifestyle habits. Serum samples will be sent for centralised analyses in Nice. This study will help to clarify the results from single center studies, such as the prognostic value of epitope spreading. The information acquired on environmental risk factors will help us understand the pathophysiological mechanisms leading to the onset of MN et, by association, to other auto-immune diseases. With this knowledge, measures could be put in place to protect the population at risk. Fermer le détail

Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
HOPITAL NOVO	MONTSENY	En recrutement IDF	18/09/2025 17:50:08	Contacter
Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU de Nice, Hôpital de l'Archet - 06200 - Nice - Alpes Maritime - France	Barbara Seitz-Polski			Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

- Age 18 years or more

- Biopsy on a native kidney consistent with MN and/or positivity for serum anti-PLA2R1
and/or anti-THSD7A antibodies

- Signed informed consent

Exclusion Criteria:

Critère de non inclusion

- Diagnosis error based on the kidney biopsy staining or on serology analyses for the
positivity for anti-PLA2R1 and/or anti-THSD7A

- Patients unable to give an informed consent

- Patients withdrawing an informed consent

NCT04326218 - Immunopathological Analysis in a French National Cohort of Membranous Nephropathy (IHMN)

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Etablissements
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