Informations générales (source: ClinicalTrials.gov)
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Interventional
N/A
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
juin 2020
juin 2026
17 septembre 2025
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive
Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI :
amnestic mild cognitive impairment), or to other neurodegenerative diseases such as
frontotemporal dementia or Lewy body diseases.
These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography)
and adaptive optics (AO) appear different depending on the pathologies and could
therefore serve as markers in vivo of the pathophysiological processes underlying NCD.
No study to date has studied the retina and its vessels in NCD using adaptive optics. In
this pilot study, we are proposing a combination of two new ophthalmological imaging
techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely
non-invasive way of the morphology of small vessels as well as architecture of the retina
to better specify the retinal anomalies associated with NCD. We will compare the
parameters in OCT-A and AO between patients with NCD and controls without NCD (with
memory complaint or without) and will seek to determine if there are different profiles
according to the causes of NCD.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Antoine MOULIGNIER | 21/06/2024 13:33:10 | Contacter | ||
Critères
Tous
Inclusion Criteria:
- Patient presenting in memory consultation for memory complaint or person
accompanying a patient in memory consultation for memory complaint
- Patient presenting in memory consultation for memory complaint or person
accompanying a patient in memory consultation for memory complaint
- pregnant or lactating women
- history of known non-degenerative neurological pathology (tumor, stroke territorial,
in particular multiple sclerosis)
- history of retinal pathology
- ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5
diopters on the cylinder.
- history of taking ethambutol for more than 2 months
- history of takingsynthetic antimalarial for more than 2 years
- Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) <10 for
patients and 26 for accompanying persons
- MRI contraindication (for patients only)