Informations générales (source: ClinicalTrials.gov)
Study of Clinical, Biological and Genetic Prognostic Factors of SARS-CoV-2 Infection in Patients Admitted in the Strasbourg University Hospitals (Covid-HUS)
Observational
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
mars 2020
mars 2022
29 juin 2024
COVID-19 is an emerging disease, for which no specific treatment options are currently
available. Since the end of February 2020, and due to a SARS-CoV-2 superspreading event
(religious meeting), the Strasbourg University Hospital (HUS) had faced a sudden increase
of the number of COVID-19-positive patients in serious condition requiring
hospitalization. At the same time, many people develop only mild or moderate symptoms. To
date, the prognostic factors for the course of SARS-CoV-2 infection are unknown. The
primary purpose of the "COVID-HUS" protocol is to investigate viral and host-related
factors to understand the pathophysiology of COVID infection and to open the way for new
diagnostic, prognostic and therapeutic strategies against SARS CoV-2 .
The secondary objectives are
- Monitoring of viral replication of SARS-CoV-2 in the blood and respiratory tract in
infected patients
- Monitoring of the humoral and cellular response directed against SARS-CoV-2
- Identification of factors leading to significant and / or prolonged viral
replication of SARS-CoV-2 in the blood or respiratory samples
- Evaluation of the benefit of possible treatments implemented following the diagnosis
of SARS-CoV-2 infection
- Exploration of the B and T immune repertoire sequences targeting SARS-CoV-2 in
infected patients
- Typing of the HLA system in infected patients
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service de Virologie - Hôpital Civil - 67091 - Strasbourg - France | Samira FAFI-KREMER, PharmD, PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Adult and pediatric with suspicion or a confirmed SARS-CoV-2 infection
- Patient who has signed a non-opposition form (or a form signed by a family member or
a support person if the seriousness of the patient's condition and the emergency
situation do not allow it) or who has given his oral agreement to the doctor
- Adult and pediatric with suspicion or a confirmed SARS-CoV-2 infection
- Patient who has signed a non-opposition form (or a form signed by a family member or
a support person if the seriousness of the patient's condition and the emergency
situation do not allow it) or who has given his oral agreement to the doctor
- Patient's explicit refusal to participate
- Subject deprived of liberty or subject to the protection of justice
- Subject under guardianship or trusteeship