Informations générales (source: ClinicalTrials.gov)
Effect of IntraoperatiVe High Positive End-ExpirAtory Pressure (PEEP) With ReCruitment MAneuveRs vs Low PEEP on Major Postoperative Pulmonary Complications and Death After On-pump Cardiac Surgery in High-risk Patients: the VACARM Study (VACARM)
Interventional
N/A
Rennes University Hospital (Voir sur ClinicalTrials)
juillet 2021
juillet 2026
04 avril 2025
Controversies remain concerning the best intraoperative mechanical ventilation regimen
for major cardiac surgery. While the use of intra operative low tidal volumes is now
standard practice, the optimal level of positive end-expiratory pressure (PEEP) and the
use of recruitment maneuvers (RM) remain controversial. The aim of this study is to
compare two regimens of intraoperative mechanical ventilation on postoperative outcomes
in cardiac surgery patients at risk of postoperative pulmonary complications
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHRU Brest - Brest - France | Jean-Ferréol OILLEAU, MD | Contact (sur clinicalTrials) | |||
| CHRU Tours - Tours - France | Fabien ESPITALIER, MD | Contact (sur clinicalTrials) | |||
| CHU Nantes - Saint-Herblain - France | Bertrand ROZEC, MD | Contact (sur clinicalTrials) | |||
| CHU Poitiers - Poitiers - France | Thomas KERFONE, MD | Contact (sur clinicalTrials) | |||
| CHU Rennes - Rennes - France | Nathalie DEMAURE | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CHU Amiens-Picardie - Amiens - France | Osama ABOU ARAB, MD | Contact (sur clinicalTrials) | |||
| CHU de Dijon - Dijon - France | Pierre-Grégoire GUINOT, MD | Contact (sur clinicalTrials) | |||
| CHU de Nancy - Nancy - France | Philippe GUERCI, MD | Contact (sur clinicalTrials) | |||
| CHU de Rouen - Rouen - France | Emmanuel BESNIER, MD | Contact (sur clinicalTrials) | |||
| CHU de Toulouse - Toulouse - France | François LABASTE, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients older than 18 years-old,
- Evaluated before cardiopulmonary bypass for any cardiac surgical procedure (e.g.
coronary artery bypass grafting, valve, aorta, or combined procedures),
- With a pulmonary risk score ≥ 2
- Who gave written informed consent
- affiliated to a social security system
- Patients older than 18 years-old,
- Evaluated before cardiopulmonary bypass for any cardiac surgical procedure (e.g.
coronary artery bypass grafting, valve, aorta, or combined procedures),
- With a pulmonary risk score ≥ 2
- Who gave written informed consent
- affiliated to a social security system
- BMI > 40kg/m2 ;
- Left Ventricular Ejection Fraction < 35% ;
- Preoperative shock ;
- Aortic surgery with planned circulatory arrest ;
- Minimally invasive cardiac surgery ;
- Emergency surgery with patient unable to give written informed consent
- Heart transplantation
- Mechanical circulatory support surgery
- Pregnant or lactating women
- Adults legally protected (under judicial protection, guardianship, or supervision),
persons deprived of their liberty