Informations générales (source: ClinicalTrials.gov)

NCT04423523 En recrutement
Plasma Levels of Danger-Associated Molecular Patterns (DAMPs) in Young Children After Cardiac Surgery Under Cardiopulmonary Bypass (IMMUNOPED 2) (IMMUNOPED2)
Observational [Patient Registry]
Nantes University Hospital (Voir sur ClinicalTrials)
septembre 2020
juillet 2025
12 décembre 2024
The investigators have previously reported that cardiac surgery with CPB ( cardiopulmonary bypass) in young infants induced a drastic reduction in mHLA-DR ( Human Leucocyte Antigen) expression, which represents one of innate immune mediator. Danger-Associated Molecular Patterns (DAMPs) can elicit immune response and may subsequentely induce an immune-suppressed state. The investigators hypothesize that CPB causes excessive DAMP release, leading to the development of immune suppression. Thus, DAMPs release will be assessed in patients undergoing CBP, and consequences on immune suppression will be evaluated.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Nantes University Hospital - 44093 - Nantes - France Alexis Chenouard, ph En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- Patient admitted to pediatric intensive care at Nantes University Hospital after
cardiac surgery with bypass graft

- Age ≤ 3 months corrected age. Control group: patients less than 3 months old
following cardiac surgery without CEC or digestive surgery with a central venous
catheter.


- Futility of care with cessation of blood tests as part of a limitation of active
therapies;

- Absence of parents for information

- Refusal of parents after information (Lack of parental consent)

- Blood volume collected for medical purposes incompatible with the needs of the
research