Informations générales (source: ClinicalTrials.gov)
Exploration by UHF MRI of Hypothalamic Networks Associated to Feeding in Obesity and Anorexia (HYPOTHALNET)
Interventional
N/A
Assistance Publique Hopitaux De Marseille (Voir sur ClinicalTrials)
juin 2020
décembre 2021
29 juin 2024
Food intake is a motivated behaviour that consists of seeking, selecting and ingesting
nutritional resources from the environment. Its main function is therefore, depending on
these conditions, to ensure the supply, in adequate quantities, of the energy and
biochemical substrates necessary for the proper functioning and need of the body. Thus,
in addition to maintaining the body's fat mass level stable, dietary behaviour is part of
the energy homeostasis system and is thus regulated and maintained by the central nervous
system.
Although diet regulation involves several brain regions, the way in which these different
regions communicate with each other and influence each other to orchestrate appropriate
eating behaviour is not yet fully characterized. Among the structures of this network,
the hypothalamus, a small structure (less than 1 cm3 in humans) composed of several
nuclei such as the lateral hypothalamus, the arched nucleus or the lateral tuberal
nucleus plays a crucial role.
The investigators propose to use ultra high field (7T) magnetic resonance imaging
equiping the CEMEREM (CHU Timone, APHM, Marseille) to better characterize the role of
this crucial small structure in food intake networks in order to better understand the
impact of these structural and functional disorders observed in patients with anorexia
nervosa and obesity compared to a control population without eating behaviour disorders.
Etablissements
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Assistance Publique Hôpitaux de Marseille - 13005 - Marseille - France | Maxime Guye, MD | Contact (sur clinicalTrials) | |||
Critères
Femme
Inclusion Criteria:
- No depression (HADS and BECK scores)
- No contraindication to 7T MRI
- Subject with with social insurance
- Subject who has signed the informed consent
For obese patients
- Body mass index > 30kg/m2
- Body diameter < 60cm (compatible with 7T MR scanner tube)
For anorexic patients
- mental anorexia according to DMS-V
- Body mass index < 17kg/m2
For healthy controls
- 18.5kg/m2<Body mass index < 25kg/m2
- no feeding behavioral disturbance (SCOFF and EAT 26)
- No depression (HADS and BECK scores)
- No contraindication to 7T MRI
- Subject with with social insurance
- Subject who has signed the informed consent
For obese patients
- Body mass index > 30kg/m2
- Body diameter < 60cm (compatible with 7T MR scanner tube)
For anorexic patients
- mental anorexia according to DMS-V
- Body mass index < 17kg/m2
For healthy controls
- 18.5kg/m2<Body mass index < 25kg/m2
- no feeding behavioral disturbance (SCOFF and EAT 26)
- Pregnant or parturiente woman
- subject with other neurological or neuropsychiatric diseases
- subject with addiction