Informations générales (source: ClinicalTrials.gov)
Study of Remission Factors in Anorexia Nervosa of Adult Women (REMANO) (REMANO)
Observational
Institut National de la Santé Et de la Recherche Médicale, France (Voir sur ClinicalTrials)
avril 2021
septembre 2025
31 juillet 2024
Anorexia Nervosa (AN) is a complex and multifactorial psychiatric disease that affects
mostly women and is characterized by a self-restriction of food intake leading to
life-threatening consequences whose underlying mechanisms are largely unexplored. AN
encompasses a constellation of risk factors including genetic, biological,
neuro-psychological and social factors. Although AN has a prevalence of only 1-3% in the
general population, it has the highest mortality rate amongst any psychiatric disorder.
Recovery of normal feeding behaviour in patients often requires several months with a
large between-patient variability and a high percentage of relapse, which can occur in 35
to 41% of the patients. There is a huge unmet need for optimal understanding of processes
underlying relapse. Reward processing abnormalities represents an important hypothesis
underlying AN development and perpetuation. We aim to investigate the mechanisms that
contribute to the maintenance and chronicity of the disease after inpatient treatment
with a longitudinal design across intensive standardized inpatient treatment. We will
challenge our hypothesis through brain imaging, neuropsychological, metabolic and genetic
approaches. One hundred twenty-five AN female patients admitted for intensive inpatient
treatment will be recruited and evaluated: at admission, after weight recovery and at 6
months after discharge with neurocognitive tests (including the Delay Discounting Task),
genetic/epigenetic examination, hormonal blood samples (at each visit and repeated
sampling around a meal for a 10-patient subgroup) and brain imaging (including fMRI
during a Delay Discounting Task for fifty patients). One hundred healthy controls will be
also recruited and be subjected to the same study procedures.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| GHU PARIS PSY ET NEUROSCIENCES | Contact (sur clinicalTrials) | ||||
Critères
Femme
Inclusion Criteria:
- DMS 5 criteria for Anorexia Nervosa
- BMI < 18.5 kg/m²
- Being able to consent
- fluent in French
- Being affiliated to a social security scheme or being the beneficiary of such a
scheme.
- Having signed the informed consent
- DMS 5 criteria for Anorexia Nervosa
- BMI < 18.5 kg/m²
- Being able to consent
- fluent in French
- Being affiliated to a social security scheme or being the beneficiary of such a
scheme.
- Having signed the informed consent
- Deprived of liberty subject (judicial or administrative decision)
- Refusal to participate
- Presenting an unstabilized serious physical illness or psychiatric disorder
compromising the follow up according investigator evaluation
- Contraindication for IRMf
- Pregnant or breast-feeding women