Informations générales (source: ClinicalTrials.gov)
Adaptive Optics (AO) Analysis of Retinal Arteries in Patients With Recent Stroke (STROKAO) (STROKAO)
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
janvier 2021
janvier 2025
29 juin 2024
The eye has long been recognized as a window to pathological processes occurring in the
brain. By imaging the vascular system of the retina scientific understanding and clinical
practice have been improved for a wide range of pathologies from diabetes to stroke and
dementia.
Adaptive optics (AO) reveals retinal details that remain invisible with other current
imaging techniques. Indeed, vessels can be perfectly visualized, making it possible to
detect wall irregularities, accurately measure their different structures and monitor
their evolution under treatment if necessary.
In AO, studies on retinal vessels involve the calculation of wall thickness (WT), outer
diameter (OD), inner diameter (ID), wall cross-sectional area (WCSA) and wall to lumen
ratio (WLR). An increase in WLR > 0.31 is characteristic of hypertensive microangiopathy
and predictive of cardiovascular and brain damage. This accurate assessment of
microvascular structure may even be required in the near future in all patients with
arterial hypertension. For vessels > 300 microns in diameter, the increase in vessel wall
thickness occurs without changing the ID, a process known as external hypertrophic
remodeling. For small arteries < 300 microns, remodeling occurs differently. The total
volume of the vessel wall remains constant, but the OD and ID each decrease, a process
known as inward eutrophic remodeling.
The objective of this study is to describe the parameters measured in AO in patients in
the acute phase of a stroke and then at 3 months.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Sophie BONNIN | 21/06/2024 13:33:34 | Contacter | ||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hôpital Fondation A. de Rothschuld - 75019 - Paris - France | Martine MAUGET FAYSSE, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- For the patients with stroke: Inpatients with confirmed stroke (clinical and
imaging) for less than 10 days
- For the controls: Individuals presenting at the Rothschild Foundation Hospital with
no history of stroke who are matched to cases already included in the matching
criteria: Age ± 5 years, Gender, high blood pressure (no history, untreated,
treated) Diabetes (Yes, No), Body Mass Index (BMI < 25, 25 ≥ BMI < 30, BMI ≥ 30)
- For the patients with stroke: Inpatients with confirmed stroke (clinical and
imaging) for less than 10 days
- For the controls: Individuals presenting at the Rothschild Foundation Hospital with
no history of stroke who are matched to cases already included in the matching
criteria: Age ± 5 years, Gender, high blood pressure (no history, untreated,
treated) Diabetes (Yes, No), Body Mass Index (BMI < 25, 25 ≥ BMI < 30, BMI ≥ 30)
- Pregnant or breastfeeding woman
- Insufficient state of consciousness or physical condition to perform the adaptive
optics examination
- For the patients with stroke: Hemorrhagic post-traumatic hematoma stroke type, or
symptomatic stroke of a brain tumour or an arteriovenous malformation.