Informations générales (source: ClinicalTrials.gov)
Biomarkers algOrithm for strOke diagnoSis and Treatment Resistance Prediction
Observational
Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)
mars 2021
juillet 2025
02 octobre 2025
Triage of acute ischemic stroke (AIS) patients is critical, to decrease time to
treatment, and improve functional outcome. The therapeutic standard of care for AIS
consecutive to large vessel occlusion (LVO) is the association of intravenous (IV)
alteplase administration and mechanical thrombectomy (MT). However, there are limited
places where MT can be performed. Therefore, there is a need for innovative tools to
identify, in the ambulance, patients with LVO that require MT. Sending the patients at
the right, avoiding futile stops (i.e. in places where MT is not available), is
definitively a strategy that saves time.
There is currently no biomarker nor Point Of Care (POC) Lab Testing to solve this issue
and clinical scoring methods such as the NIHSS have a low accuracy rate to detect LVO.
The relevance of blood biomarkers for LVO diagnosis and therapeutic decisions needs to be
confirmed for effective triage in the setting of AIS with LVO, which represent 30% of all
AIS.
The main objective of our study is to determine diagnostic performances of a panel of
selected blood biomarkers to identify patients with AIS consecutive to LVO among those
with stroke suspicion, within 24 hours of stroke symptom's onset before brain imaging.
This could facilitate the triage of patients with LVO refractory to thrombolysis
treatment, who may benefit most from MT.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | BERTRAND LAPERGUE | 15/12/2025 08:26:10 | Contacter | ||
| HOPITAL FONDATION A. DE ROTHSCHILD | MAZIGHI Mikael | 13/12/2025 07:27:55 | Contacter | ||
| AP-HP Assistance publique - Hôpitaux de Paris | 13/12/2025 07:27:56 | Contacter | |||
| AP-HP - Hôpital Lariboisiere-Fernand Widal | |||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Department Neurology Caen Hospital - Caen 3029241 - France | Contact (sur clinicalTrials) | ||||
| Hospital Foch - Suresnes 2973675 - France | Contact (sur clinicalTrials) | ||||
| Lariboisière - 75010 - Paris 2988507 - France | Contact (sur clinicalTrials) | ||||
| Rothschild Foundation Hospital - Paris 2988507 - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
- Symptoms consistent with stroke <24 hours
- Adult patients ≥ 18 years old
- Non opposition of the patient or his/her relatives to the research (emergency
inclusion procedure)
Exclusion Criteria:
- Patient under guardianship or curatorship