Informations générales (source: ClinicalTrials.gov)
Evaluation of the Efficacy of Dornase Alfa (Pulmozyme®) on Arterial Recanalization in Post-thrombectomy Angiography in Patients with Ischemic Stroke by Thrombolysis and Eligible for Thrombectomy (NETs-target) (NETs-target)
Interventional
Phase 2
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
août 2022
novembre 2025
09 octobre 2024
The functional prognosis of patients with ischaemic stroke treated by thrombolysis and
thrombectomy is associated with complete reperfusion of the occluded artery defined by an
mTICI 2C or 3 score at the end of thrombectomy. However, this complete reperfusion is
only obtained in 60% of patients. Most often, incomplete reperfusion is due to the
persistence of distal occlusions, which are inaccessible to mechanical thrombectomy. Drug
treatment, combined with thrombectomy to increase the rate of complete reperfusion, would
be a major advance in the management of these patients.
This is a non-randomized, monocentric, open-label, phase II trial to evaluate efficacy of
dornase alfa intravenous administration in patients treated with intravenous thrombolysis
and eligible for thrombectomy for ischemic stroke of the anterior circulation.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Jean-Philippe DESILLES | 21/06/2024 13:34:11 | Contacter | ||
Critères
Tous
Inclusion Criteria:
- Ischemic stroke by proximal intracranial occlusion (internal carotid artery, middle
cerebral artery in its M1 or M2 segment) isolated from the anterior circulation
eligible for cerebral thrombectomy.
- Transferred to the NRI block for a cerebral thrombectomy.
- Treated by thrombolysis intravenous (Aleplase or Tenecteplase) as recommanded by
European stroke organisation
- With DWI-ASPECT score>5 to MRI
- Ischemic stroke by proximal intracranial occlusion (internal carotid artery, middle
cerebral artery in its M1 or M2 segment) isolated from the anterior circulation
eligible for cerebral thrombectomy.
- Transferred to the NRI block for a cerebral thrombectomy.
- Treated by thrombolysis intravenous (Aleplase or Tenecteplase) as recommanded by
European stroke organisation
- With DWI-ASPECT score>5 to MRI
- Pregnant or breastfeeding woman
- Known allergy to Dornase alfa or one of its excipients.