Informations générales (source: ClinicalTrials.gov)
Amotivational Syndrome and Fatigue in Neurosurgery: The Impact of Neuroinflammation
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
décembre 2021
décembre 2024
03 décembre 2025
Depression is a major public concern associated with profound distress, intense
suffering, and impairment in social, professional and familial functioning. Among the
numerous symptoms defining depression, fatigue and motivation are not only frequent but
also highly associated with poor quality of life and resistance to conventional
antidepressant. Recent data, mainly obtained in animals, suggest that these symptoms may
be linked to inflammatory processes within the central nervous system. Yet access to the
brain is too invasive for exploring this link in patients with psychiatric conditions.
However, certain conditions in neurosurgery, such as aneurysm rupture, require external
evacuation, over several days or weeks, of the fluid bathing the brain through a catheter
directly inserted into it. Critically, these patients also exhibit extreme exhaustion and
fluctuating motivation, allowing to investigate the involvement of neuroinflammation in
lack of motivation and fatigue by carrying out repeated motivation assessments with short
behavioral tests (around ten minutes), while performing an analysis of inflammation
markers in the fluid evacuated from the brain. The identification of inflammatory
mechanisms underlying lack of motivation and fatigue could lead to the development of
treatments for both resistant depression and motivation deficits that largely hamper
rehabilitation in neurosurgery.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Pierre BOURDILLON | 21/06/2024 13:33:58 | Contacter | ||
Critères
Tous
Inclusion Criteria:
- Age >= 18 years old
- Patients required an external cerebrospinal fluid drainage
- Age >= 18 years old
- Patients required an external cerebrospinal fluid drainage
- Pregnant or breast feeding patient
- Patient under legal protection
- Patient opposition to participate in this study