Informations générales (source: ClinicalTrials.gov)
Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State" (SENSE)
Interventional
N/A
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
avril 2022
septembre 2024
29 juin 2024
Essential trigeminal neuralgia is the most common facial pain. In forms resistant to drug
and disabling treatments, surgical treatment may be offered to the patient. The type of
intervention will be conditioned by the presence or absence of a vasculo-nervous conflict
objectified by MRI(Magnetic resonance imaging) Morphological MRI with contrast injection
does not always allow an accurate assessment of trigeminal nerve damage in patients with
essential facial neuralgia. Despite advances in the anatomical definition of
high-resolution MRI, the correlation between a vascular conflict visible on MRI and
present during surgery and prolonged postoperative clinical improvement remains
insufficient These data raise the question of additional imaging sequences to assess the
distressing characteristics of NT in addition to the usual anatomical criteria for
compression By performing during morphological MRI two additional sequences, one in
diffusion tensor (DTI) and one in resting state (fMRI), we could better characterize the
achievement of NT
The contribution of new imaging sequences in the context of essential trigeminal
neuralgia treated with microvascular decompression (MVD) would:
1/improve the diagnostic criteria for suffering and compression of the NT (trigeminal
nerve) 2 / define objective prognostic criteria for the effectiveness of surgery,
particularly in the context of unusual clinical symptoms or moderate conflict on MRI
(Magnetic resonance imaging) 3 / to analyze more precisely the causes of recurrence at a
distance from surgery and help in the decision of re-intervention Our main hypothesis:
the addition of a diffusion tensor sequence and sequences (allowing functional brain
analysis) in addition to standard anatomical MRI in the assessment of a vasculo-nervous
conflict would allow us to better characterize involvement of the trigeminal nerve in
essential facial neuralgia. It also helps guide therapeutic management and surgical
indications.
This is a prospective, monocentric cohort study. It will be offered to patients referred
to neurosurgery or to the pain assessment and treatment center for assessment and
management of a neuralgia of the essential trijumeau unilateral.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Amélie Yavchitz | 21/06/2024 13:33:42 | Contacter | ||
Critères
Tous
Inclusion Criteria:
- Adult patients (18 years and over);
- Supported in the neurosurgery department or at the assessment and treatment center
for pain for unilateral essential trigeminal neuralgia with search for
vasculo-nervous conflict;
- Adult patients (18 years and over);
- Supported in the neurosurgery department or at the assessment and treatment center
for pain for unilateral essential trigeminal neuralgia with search for
vasculo-nervous conflict;
- Patient with neurodegenerative or inflammatory neurological pathology;
- Patient who has already been operated on for a DMV;
- Absolute contraindication to MRI
- Patient benefiting from a legal protection measure; with impaired judgment skills or
unable to receive information;
- Pregnant or breastfeeding women