Informations générales (source: ClinicalTrials.gov)
Biological Characterization of Advanced ALK-rearranged Non-small Cell Lung (NSCLC) Cancer Included in EXPLOREALK Study (BIOEXALK)
Interventional
N/A
Groupe Francais De Pneumo-Cancerologie (Voir sur ClinicalTrials)
septembre 2021
juin 2027
07 août 2025
BioEXALK is a prospective study evaluating the biological characteristics of advanced
ALK-rearranged NSCLC treated with next generation TKIs in first line, included in the
national EXPLORE ALK cohort (GFPC 03-2019), a non-interventional, national, multi-center
cohort of ALK-rearranged NSCLC patients.
BioExALK study will be proposed to every patient included in the Explore ALK GFPC 03-2019
study.
Biological analysis will be performed on tumor tissue at diagnosis and at the time of
disease progression when available and on circulating tumor DNA (ctDNA).
For plasma testing, after obtained patient consent, blood samples will be taken and
analyzed at the Léon Bérard Center (Lyon).
Biological analysis on tissue obtained at diagnosis and at disease progression will be
collected and be sent for centralized analysis to the Rouen University Hospital.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CH DE VERSAILLES SITE ANDRE MIGNOT | Cécile DUJON | Contact (sur clinicalTrials) | |||
| CHI DE CRETEIL | Gaelle ROUSSEAU-BUSSAC, PhD | Contact (sur clinicalTrials) | |||
| CLCC INSTITUT CURIE | Catherine DANIEL | Contact (sur clinicalTrials) | |||
| CLCC INSTITUT GUSTAVE ROUSSY | Benjamin BESSE | Contact (sur clinicalTrials) | |||
| HOPITAL FOCH | Hélène DOUBRE | lundi 25 août 2025 | Contact (sur clinicalTrials) | ||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre François Baclesse - 14000 - Caen - France | Radj GERVAIS | Contact (sur clinicalTrials) | |||
| Centre Hospitalier d'Aix en Provence - 13616 - Aix En Provence - France | Stéphanie MARTINEZ | Contact (sur clinicalTrials) | |||
| Centre Hospitalier d'Annecy - 74374 - Annecy - France | Chantal DECROISETTE | Contact (sur clinicalTrials) | |||
| Centre Hospitalier de Villefranche sur Saone - 69655 - Villefranche Sur Saone - France | Lionel FALCHERO | Contact (sur clinicalTrials) | |||
| Centre Hospitalier du Morvan - 29200 - Brest - France | Renaud DESCOURT, PhD | Contact (sur clinicalTrials) | |||
| Centre Hospitalier Universitaire - 49033 - Angers - France | Thierry URBAN | Contact (sur clinicalTrials) | |||
| Centre Léon Bérard - 69373 - Lyon - France | Aurélie SWALDUZ | Contact (sur clinicalTrials) | |||
| Centre Paul Strauss - 67065 - Strasbourg - France | Roland SCHOTT, PhD | Contact (sur clinicalTrials) | |||
| CHU La Réunion Site Sud - 97410 - Saint-Pierre - France | Eric HUCHOT | Contact (sur clinicalTrials) | |||
| CHU Pontchailloux - 35000 - Rennes - France | Charles RICORDEL, PhD | Contact (sur clinicalTrials) | |||
| Hôpital Charles Nicolle - 76031 - Rouen - France | Florian GUISIER | Contact (sur clinicalTrials) | |||
| Hôpital de Meaux - 77100 - Meaux - France | Chrystèle LOCHER, PhD | Contact (sur clinicalTrials) | |||
| Hôpital d'Instruction des Armées Ste Anne - 83800 - Toulon - France | Olivier BYLICKI | Contact (sur clinicalTrials) | |||
| Hôpital du Haut Leveque - 33604 - Pessac - France | Rémi VEILLON | Contact (sur clinicalTrials) | |||
| Hôpital du Scorff - 56100 - Lorient - France | Régine LAMY | Contact (sur clinicalTrials) | |||
| Hôpital Larrey - 31059 - Toulouse - France | Laurence BIGAY-GAME | Contact (sur clinicalTrials) | |||
| Hôpital Nord - 13915 - Marseille - France | Laurent GREILLIER | Contact (sur clinicalTrials) | |||
| Institut Lucien Neuwirth - 42271 - Saint-Priest-en-Jarez - France | Pierre FOURNEL | Contact (sur clinicalTrials) | |||
| Oncologie Centre Oscar Lombret - 59000 - Lille - France | Eric DANSIN | Contact (sur clinicalTrials) | |||
| Oncologie CH Bretagne-Atlantique - 56000 - Vannes - France | Gonzague DE CHABOT | Contact (sur clinicalTrials) | |||
| Oncologie CH Morlaix - 29600 - Morlaix - France | Karim AMRANE | Contact (sur clinicalTrials) | |||
| Oncologie CLCC Jean Perrin - 63000 - Clermont-Ferrand - France | Lise THIBONNIER | Contact (sur clinicalTrials) | |||
| Oncologie Hôpital François Quesnay - 78200 - Mantes-la-Jolie - France | Karima SABOUNDJI | Contact (sur clinicalTrials) | |||
| Oncologie Institut du Cancer de Montpellier - 34298 - Montpellier - France | Camille TRAVERT | Contact (sur clinicalTrials) | |||
| Oncologie Institut Paoli Calmette - 13273 - Marseille - France | Anne MADROSZYK | Contact (sur clinicalTrials) | |||
| Pneumologie Centre Hospitalier - 64000 - Pau - France | Aldo RENAULT | Contact (sur clinicalTrials) | |||
| Pneumologie CH - 72000 - Le Mans - France | Olivier MOLINIER | Contact (sur clinicalTrials) | |||
| Pneumologie CH Eure-Seine - 27000 - Évreux - France | Nicolas DELBERGHE | Contact (sur clinicalTrials) | |||
| Pneumologie CH Métropole Savoie - 73000 - Chambéry - France | Julian PINSOLLE | Contact (sur clinicalTrials) | |||
| Pneumologie CHD Vendée - 85925 - La Roche-sur-Yon - France | Marie MARCQ | Contact (sur clinicalTrials) | |||
| Pneumologie CHI - 94195 - Villeneuve-Saint-Georges - France | Alexa MAIROVITZ | Contact (sur clinicalTrials) | |||
| Pneumologie CHR - 45000 - Orléans - France | Hugues H MOREL | Contact (sur clinicalTrials) | |||
| Pneumologie CHU - 80054 - Amiens - France | Géraldine FRANCOIS | Contact (sur clinicalTrials) | |||
| Pneumologie CHU Félix Guyon - 97400 - Saint-Denis - La Réunion - France | Diane MOREAU | Contact (sur clinicalTrials) | |||
| Pneumologie CHU Limoges - 87042 - Limoges - France | Yannick SIMONNEAU | Contact (sur clinicalTrials) | |||
| Pneumologie HIA - 33400 - Talence - France | Jean-Michel PELONI | Contact (sur clinicalTrials) | |||
| Pneumologie Hôpital Calmette - 59000 - Lille - France | Alexis CORTOT | Contact (sur clinicalTrials) | |||
| Pneumologie Hôpital Européen - 130003 - Marseille - France | Jacques LE TREUT | Contact (sur clinicalTrials) | |||
| Pneumologie Hôpital privé Jean Mermoz - 69085 - Lyon - France | Pierre BOMBARON | Contact (sur clinicalTrials) | |||
| Pneumologie Hôpital Sainte Musse - 83056 - Toulon - France | Clarisse AUDIGIER VALETTE | Contact (sur clinicalTrials) | |||
| Pneumologie Hôpital Yves Le Foll - 22000 - Saint-Brieuc - France | Gwenaelle LE GARFF | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Stage IIIB/IV NSCLC non eligible to locoregional treatment with curative intent
- ALK rearrangement confirmed by IHC and/or FISH or NGS according to local methods
- Patient included in the EXPLORE ALK study
- Age > or = 18 years
- Patient treated with first-line new generation ALKi
- Patient agrees to sign an informed consent form and to collect blood samples at
inclusion, first tumor evaluation and progression and for whom tumor biopsy at
diagnosis is available
- Patient enrolled in the french National Health Insurance program or with a third-
party payer
- Stage IIIB/IV NSCLC non eligible to locoregional treatment with curative intent
- ALK rearrangement confirmed by IHC and/or FISH or NGS according to local methods
- Patient included in the EXPLORE ALK study
- Age > or = 18 years
- Patient treated with first-line new generation ALKi
- Patient agrees to sign an informed consent form and to collect blood samples at
inclusion, first tumor evaluation and progression and for whom tumor biopsy at
diagnosis is available
- Patient enrolled in the french National Health Insurance program or with a third-
party payer
- Patients who do not wish to participate in Bioexalk
- Patients under guardianship