Informations générales (source: ClinicalTrials.gov)
Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma: a Prospective Single-center Cross-sectional Case-control Study (GLAUCALYX)
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
mai 2022
mai 2026
23 mai 2025
The glycocalyx is a fibrillary lining structure that covers the inner surface of blood
vessels. Composed of glycoproteins and polysaccharides, it is an essential determinant of
vascular endothelial physiology: it limits coagulation activation and adapts capillary
perfusion. Studies have shown glycocalyx alteration in various vascular and autoimmune
pathologies such as diabetes, high blood pressure, chronic renal failure, ischemic heart
disease, stroke, dementia, septic shock, and several other inflammatory pathologies with
a common basis in vascular insufficiency.
Glaucoma is a progressive, chronic and asymptomatic optic neuropathy characterized by
visual field damage and abnormalities of the optic nerve head. Two hypotheses have been
proposed as a basis for this progressive damage:
- the mechanical theory, which explains the papillary excavation by a compression of
the optic nerve head under the effect of high intraocular pressure; and
- the ischemic theory, explained by a circulatory insufficiency at the level of the
blood capillaries of the retina and especially of the optic nerve head. This latter
theory is related to several pathologies that have circulatory insufficiency as
common underlying pathophysiology, and in which damage to the glycocalyx has been
well studied.
Glycocalyx damage has rarely been studied in glaucoma. Yang et al. showed that the
glycocalyx, present in Schlem's canal, plays a major role in the transduction of shear
stress and regulation of outflow resistance to the aqueous humor, which may constitute an
interesting biomarker for glaucomatous pathologies.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Cédric LAMIREL | 21/06/2024 13:34:22 | Contacter | ||
Critères
Tous
Inclusion Criteria:
- Express consent to participate in the study
- Only for case group: primary open angle glaucoma (defined as the presence of visual
field damage attributed to glaucomatous optic neuropathy) in both eyes
- Only for control group: Absence optic nerve pathology (including primary open angle
glaucoma)
- Express consent to participate in the study
- Only for case group: primary open angle glaucoma (defined as the presence of visual
field damage attributed to glaucomatous optic neuropathy) in both eyes
- Only for control group: Absence optic nerve pathology (including primary open angle
glaucoma)
- Pregnant or breastfeeding woman
- Sleep apnea
- Renal insufficiency
- Parkinson's disease
- Alzheimer's disease
- Antiphospholipid syndrome
- Cancer for which treatment ended less than 2 years ago
- Stroke less than 1 year ago
- Myocardial infarction less than 1 year ago