Informations générales (source: ClinicalTrials.gov)
Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss (AUDIOGENAGE)
Interventional
N/A
Institut Pasteur (Voir sur ClinicalTrials)
juillet 2022
décembre 2030
05 avril 2025
Age-related hearing loss, or presbycusis, is caused by many genetic and environmental
factors. Its prevalence poses a public health challenge of early identification and
effective hearing aid treatment. However, the lack of screening and of a validated
audiological test battery to diagnose an individual's needs and to guide hearing aid
adjustments is a major obstacle.
Furthermore, monogenic forms of hearing loss affect only one functional module of
hearing. The audiological test(s) dependent on the function of this module are affected,
in a progressive manner, but not the others. A previous study showed that in early onset
presbycusis patients, a quarter of the subjects tested were affected by monogenic
presbycusis.
The collection of audiological and vestibular tests, carried out on proven monogenic
presbycusis patients and compared to that of normal hearing patients, would constitute a
battery of tests allowing a precision diagnosis, then developed to all forms of
presbycusis in order to study if the identification of abnormal functional modules can
usefully guide the diagnosis and the early fitting.
Etablissements
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CEntre de Recherche et d'Innovation en Audiologie Humaine - 75012 - Paris - France | Paul Avan, MD | Contact (sur clinicalTrials) | |||
| Laboratoire de correction auditive - 75001 - Paris - France | Arnaud Coez, PharmD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
For all participants:
- Be over the age of 18,
- Be affiliated to a social security system,
- Have a good command of the French language (oral and written).
For the group of participants with anticipated presbycusis:
- Over the age of 40, having a hearing aid recipient or coming for a first hearing aid
recipient
- Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid
recipient or declare a progressive genetic birth defect
For healthy volunteers:
- Have no known hearing loss.
For all participants:
- Be over the age of 18,
- Be affiliated to a social security system,
- Have a good command of the French language (oral and written).
For the group of participants with anticipated presbycusis:
- Over the age of 40, having a hearing aid recipient or coming for a first hearing aid
recipient
- Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid
recipient or declare a progressive genetic birth defect
For healthy volunteers:
- Have no known hearing loss.
- Report having been chronically exposed to loud sounds.
- Have a history of ototoxic substances,
- To have sequelae of ear infections and/or a history of ENT disease that permanently
affects hearing or balance,
- Have an ethnic origin for which the Pasteur Institute does not have information on
the frequency of variants of the genes studied.
- Have type II diabetes,
- Have a neurological or psychiatric condition that interferes with comprehension or
ability to move,
- Be under guardianship,
- Be deprived of liberty by judicial or administrative decision, or be subject to
legal protection,
- Not being subject to a social security system,
- Taking narcotic substances, alcohol or medication that diminishes cognitive
abilities.