Informations générales (source: ClinicalTrials.gov)
Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients (CICASAND)
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
mai 2023
septembre 2025
23 mai 2025
Keratopathy of patients with aniridia leads to epithelial scarring disorders and a
progressive clouding of the cornea linked to this abnormal healing (fibrosis). Treatment
with autologous serum is usually undertaken to promote epithelial healing.
However, autologous serum does not prevent the formation of fibrosis, whereas growth
factor-rich plasma appears to be associated with a reduction in the in vitro expression
of fibrosis markers. This study seeks to compare the in vitro healing and anti-fibrotic
properties of autologous serum and growth factor rich plasma from aniridia patients and
healthy controls.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Damien GUINDOLET | 21/06/2024 13:34:39 | Contacter | ||
Critères
Tous
Inclusion Criteria:
For patients with aniridia:
- With aniridia
- Patient weighing more than 43 kg
- If the patient is being treated with autologous serum, a delay of 8 weeks after the
last blood collection
- If a blood donation has been made, a delay of 8 weeks must be respected after the
last donation
For controls:
- Non-aniridia (no clinical signs)
- Weighing more than 43 kg
- Matched to a case for sex and age +/-10 years
- No known diabetes
- If a blood donation has been made, a delay of 8 weeks must be respected after the
latter
For patients with aniridia:
- With aniridia
- Patient weighing more than 43 kg
- If the patient is being treated with autologous serum, a delay of 8 weeks after the
last blood collection
- If a blood donation has been made, a delay of 8 weeks must be respected after the
last donation
For controls:
- Non-aniridia (no clinical signs)
- Weighing more than 43 kg
- Matched to a case for sex and age +/-10 years
- No known diabetes
- If a blood donation has been made, a delay of 8 weeks must be respected after the
latter
- Insufficient sample volume
- No conjunctival print
- HBV, HCV, HIV serology positive
- Aniridia not genetically confirmed for cases For each patient excluded, a new
patient will be included in order to maintain the number of patients required for
data analysis.