Informations générales (source: ClinicalTrials.gov)
Oral Health and Wilson's Disease: SOMAWI (SOMAWI)
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
mai 2023
octobre 2026
17 octobre 2024
Patients with Wilson disease have poorer dental and periodontal health and a have lower
oral quality of life than control patients. Patients with a neurological form would also
more frequently present limitations in the function of the masticatory apparatus.
Systemic treatments for Wilson disease are associated with lesions of the oral mucosa.
Analysis of copper level in saliva could testify to the effectiveness of copper depletion
in treated patients The main objective is to compare the state of dental health between:
patients with Wilson disease in the hepatic form and patients with the neurological form,
and a population of controls.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Aurélia POUJOIS | 21/06/2024 13:34:37 | Contacter | ||
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - Hôpital Charles Foix | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- Express consent to participate in the study
- Member of or beneficiary of a social security scheme
- For cases: Affected by Wilson's disease
- For controls: Benefiting from a first routine dental consultation with dental
panoramic imaging, outside of an emergency context or treatment
follow-up/maintenance
- Express consent to participate in the study
- Member of or beneficiary of a social security scheme
- For cases: Affected by Wilson's disease
- For controls: Benefiting from a first routine dental consultation with dental
panoramic imaging, outside of an emergency context or treatment
follow-up/maintenance
- Patient benefiting from a legal protection measure
- Pregnant or breastfeeding women
- Severe psychiatric disorders with behavioral disorders
- For cases:
- hepatic or neurological decompensation
- liver transplant patient
- For witnesses:
- Patient with hepatic or neurological disease
- Patient taking dietary supplements enriched with copper or zinc or zinc
supplementation
- Patient wearing removable prostheses with zinc-enriched prosthetic adhesives
(Fixodent ProPlus®)