Informations générales (source: ClinicalTrials.gov)
A Prospective Monocentric Study to Assess the Concordance of Lung MRI Compared to Chest CT Scan to Assess the Extent and Severity of Bronchial and Parenchymal Pulmonary Lesions in Adult Patients With Primary Immune Deficiency (PID): IRM vs SCANNER (IRMvsSCANNER)
Interventional
N/A
Hopital Foch (Voir sur ClinicalTrials)
novembre 2021
mai 2023
06 juillet 2024
Currently, there is no official recommendations for the respiratory surveillance of
patients with PID.However, it is recommended to perform a chest CT scan each 5 years or
before any significant therapeutic change.
The methods of surveillance need to meet two contradictory imperatives:
- monitor frequently enough not to diagnose with delay an aggravation of
bronchiectasis or interstitial pneumonitis, an infectious complication by a slowly
growing pathogen such as a non-tuberculous mycobacterium, or lymphoid proliferation.
- do not expose these often young patients to significant irradiation by a
considerable number of scans during their life. In addition, some patients with PID
have increased radiosensitivity without a safe irradiation threshold having been
determined.
To make thoses requirements effective, the solution is to combine radiological monitoring
and absence of irradiation. Therefore, it makes sense to study whether chest scans can be
replaced by MRI, non-irradiating imaging. But the question that needs to be answered is
whether the information provided by the chest MRI is not inferior to that provided by the
scanner.
The objective of this study is to assess the ability of MRI performed with ultrashort
echo time to analyze the extent and severity of bronchial and pulmonary parenchymal
lesions during the follow-up of patients with primary immunodeficiency, comparing them to
those of the chest CT scan.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | Louis-jean Couderc, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients aged 18 or over
- Adult patients with PID
- Patients who have performed EFR (Functional Respiratory Tests) within 6 months
- Patients who have signed a consent form
- Patients affiliated with a Health Insurance plan.
- Patients aged 18 or over
- Adult patients with PID
- Patients who have performed EFR (Functional Respiratory Tests) within 6 months
- Patients who have signed a consent form
- Patients affiliated with a Health Insurance plan.
- Pregnant woman
- Contraindications to MRI:
- Patients with magnetically activated implanted devices (cardiac pacemakers,
insulin pumps, neurostimulators, cochlear implants),
- Patients with intraocular metal or in the brain (aneurysm clip),
- Patients with prostheses in the thoracic position and contraindicated for MRI
examination
- Claustrophobic patients.
- To be deprived of liberty or under guardianship.